Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity

Henry P. Parkman, Katherine Yates, William L. Hasler, Linda Nguyen, Pankaj Jay Pasricha, William J. Snape, Gianrico Farrugia, Kenneth L. Koch, Thomas L. Abell, Richard W. McCallum, Linda A Lee, Aynur Unalparida, James A Tonascia, Frank Hamilton

Research output: Contribution to journalArticle

Abstract

Background & Aims: Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity. We studied characteristics of patients with IG enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium Registry. Methods: Data from medical histories, symptom questionnaires, and 4-hour gastric emptying scintigraphy studies were obtained from patients with IG. Results: The mean age of 243 patients with IG studied was 41 years; 88% were female, 46% were overweight, 50% had acute onset of symptoms, and 19% reported an initial infectious prodrome. Severe delay in gastric emptying (>35% retention at 4 hours) was present in 28% of patients. Predominant presenting symptoms were nausea (34%), vomiting (19%), an abdominal pain (23%). Women had more severe nausea, satiety, constipation, and overall gastroparesis symptoms. Patients who experienced acute-onset IG had worse nausea than those with insidious onset. Overweight patients had more bloating and gastric retention at 2 hours but less severe loss of appetite. Patients with severely delayed gastric emptying had worse vomiting and more severe loss of appetite and overall gastroparesis symptoms. Severe anxiety and depression were present in 36% and 18%, respectively. A total of 86% met criteria for functional dyspepsia, primarily postprandial distress syndrome. Conclusions: IG is a disorder that primarily affects young women, beginning acutely in 50% of cases; unexpectedly, many patients are overweight. Severe delay in gastric emptying was associated with more severe symptoms of vomiting and loss of appetite. IG is a diverse syndrome that varies by sex, body mass, symptom onset, and delay in gastric emptying.

Original languageEnglish (US)
Pages (from-to)101-115
Number of pages15
JournalGastroenterology
Volume140
Issue number1
DOIs
StatePublished - Jan 2011

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Gastroparesis
Gastric Emptying
Appetite
Nausea
Vomiting
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Dyspepsia
Constipation
Radionuclide Imaging
Abdominal Pain
Registries
Stomach
Anxiety
Depression

Keywords

  • Functional Dyspepsia
  • Gastric Emptying
  • Gastroparesis
  • Nausea
  • Vomiting

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. / Parkman, Henry P.; Yates, Katherine; Hasler, William L.; Nguyen, Linda; Pasricha, Pankaj Jay; Snape, William J.; Farrugia, Gianrico; Koch, Kenneth L.; Abell, Thomas L.; McCallum, Richard W.; Lee, Linda A; Unalparida, Aynur; Tonascia, James A; Hamilton, Frank.

In: Gastroenterology, Vol. 140, No. 1, 01.2011, p. 101-115.

Research output: Contribution to journalArticle

Parkman, HP, Yates, K, Hasler, WL, Nguyen, L, Pasricha, PJ, Snape, WJ, Farrugia, G, Koch, KL, Abell, TL, McCallum, RW, Lee, LA, Unalparida, A, Tonascia, JA & Hamilton, F 2011, 'Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity', Gastroenterology, vol. 140, no. 1, pp. 101-115. https://doi.org/10.1053/j.gastro.2010.10.015
Parkman, Henry P. ; Yates, Katherine ; Hasler, William L. ; Nguyen, Linda ; Pasricha, Pankaj Jay ; Snape, William J. ; Farrugia, Gianrico ; Koch, Kenneth L. ; Abell, Thomas L. ; McCallum, Richard W. ; Lee, Linda A ; Unalparida, Aynur ; Tonascia, James A ; Hamilton, Frank. / Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. In: Gastroenterology. 2011 ; Vol. 140, No. 1. pp. 101-115.
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abstract = "Background & Aims: Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity. We studied characteristics of patients with IG enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium Registry. Methods: Data from medical histories, symptom questionnaires, and 4-hour gastric emptying scintigraphy studies were obtained from patients with IG. Results: The mean age of 243 patients with IG studied was 41 years; 88{\%} were female, 46{\%} were overweight, 50{\%} had acute onset of symptoms, and 19{\%} reported an initial infectious prodrome. Severe delay in gastric emptying (>35{\%} retention at 4 hours) was present in 28{\%} of patients. Predominant presenting symptoms were nausea (34{\%}), vomiting (19{\%}), an abdominal pain (23{\%}). Women had more severe nausea, satiety, constipation, and overall gastroparesis symptoms. Patients who experienced acute-onset IG had worse nausea than those with insidious onset. Overweight patients had more bloating and gastric retention at 2 hours but less severe loss of appetite. Patients with severely delayed gastric emptying had worse vomiting and more severe loss of appetite and overall gastroparesis symptoms. Severe anxiety and depression were present in 36{\%} and 18{\%}, respectively. A total of 86{\%} met criteria for functional dyspepsia, primarily postprandial distress syndrome. Conclusions: IG is a disorder that primarily affects young women, beginning acutely in 50{\%} of cases; unexpectedly, many patients are overweight. Severe delay in gastric emptying was associated with more severe symptoms of vomiting and loss of appetite. IG is a diverse syndrome that varies by sex, body mass, symptom onset, and delay in gastric emptying.",
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