Clinical Features of HPV-Related Head and Neck Squamous Cell Carcinoma: Presentation and Work-Up

Wayne M. Koch

doi:10.1016/j.otc.2012.04.004

Clinical Features of HPV-Related Head and Neck Squamous Cell Carcinoma: Presentation and Work-Up

Wayne M. Koch

School of Medicine

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Head and neck squamous cell carcinoma (HNSCC) that arises as a result of the activity of human papillomavirus (HPV) malignant transformation has a distinct disease pattern that is the basis for its clinical presentation. A clear understanding of these distinct clinical features enables diagnosticians to maintain awareness and index of suspicion to avoid delays in detection and select the most effective and thorough measures of evaluating the disease and directing treatment selection. Attention is focused on the broader demographic at risk for developing HPV-related HNSCC, the phenomenon of cystic cervical nodal metastases, and the unknown or occult primary cancer.

Original language	English (US)
Pages (from-to)	779-793
Number of pages	15
Journal	Otolaryngologic Clinics of North America
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.otc.2012.04.004
State	Published - Aug 2012

Keywords

Cystic nodal metastasis
Palatine and lingual tonsils
Unknown primary

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/j.otc.2012.04.004

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abstract = "Head and neck squamous cell carcinoma (HNSCC) that arises as a result of the activity of human papillomavirus (HPV) malignant transformation has a distinct disease pattern that is the basis for its clinical presentation. A clear understanding of these distinct clinical features enables diagnosticians to maintain awareness and index of suspicion to avoid delays in detection and select the most effective and thorough measures of evaluating the disease and directing treatment selection. Attention is focused on the broader demographic at risk for developing HPV-related HNSCC, the phenomenon of cystic cervical nodal metastases, and the unknown or occult primary cancer.",

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AB - Head and neck squamous cell carcinoma (HNSCC) that arises as a result of the activity of human papillomavirus (HPV) malignant transformation has a distinct disease pattern that is the basis for its clinical presentation. A clear understanding of these distinct clinical features enables diagnosticians to maintain awareness and index of suspicion to avoid delays in detection and select the most effective and thorough measures of evaluating the disease and directing treatment selection. Attention is focused on the broader demographic at risk for developing HPV-related HNSCC, the phenomenon of cystic cervical nodal metastases, and the unknown or occult primary cancer.

KW - Cystic nodal metastasis

KW - Palatine and lingual tonsils

KW - Unknown primary

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JO - Otolaryngologic Clinics of North America

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Clinical Features of HPV-Related Head and Neck Squamous Cell Carcinoma: Presentation and Work-Up

Abstract

Keywords

ASJC Scopus subject areas

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