Clinical Features, Laboratory Investigations, and Survival in Ocular Reticulum Cell Sarcoma

L. Neal Freeman; Andrew P. Schachat; David L. Knox; Ronald G. Michels; W. Richard Green

doi:10.1016/S0161-6420(87)33256-7

Clinical Features, Laboratory Investigations, and Survival in Ocular Reticulum Cell Sarcoma

L. Neal Freeman, Andrew P. Schachat, David L. Knox, Ronald G. Michels, W. Richard Green

School of Medicine

Research output: Contribution to journal › Article › peer-review

192 Scopus citations

Abstract

The authors report 32 cases of histologically proven ocular reticulum cell sarcoma (RCS). Follow-up data are available for all patients. Twenty-six patients (81%) have died and the mean survival time was 20 months from the time of diagnosis of RCS. Diagnosis of ocular involvement was made by vitreous biopsy in 56% of cases, enucleation in 13%, and postmortem examination in 31%. The mean age at the time of diagnosis was 60 years. Central nervous system (CNS) involvement was present in 56% of patients, visceral involvement in 16%, and both CNS and visceral involvement in 6%. Isolated ocular disease occurred in 22% of patients. Results of head computed tomography (CT) and cerebrospinal fluid examination more often disclosed evidence of RCS than did body CT or nuclear medicine scans. Responses to treatment were variable, but prognosis for survival is poor.

Original language	English (US)
Pages (from-to)	1631-1639
Number of pages	9
Journal	Ophthalmology
Volume	94
Issue number	12
DOIs	https://doi.org/10.1016/S0161-6420(87)33256-7
State	Published - Jan 1 1987

Keywords

intraocular tumor
lymphoma
ocular inflammation
reticulum cell sarcoma

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(87)33256-7

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title = "Clinical Features, Laboratory Investigations, and Survival in Ocular Reticulum Cell Sarcoma",

abstract = "The authors report 32 cases of histologically proven ocular reticulum cell sarcoma (RCS). Follow-up data are available for all patients. Twenty-six patients (81%) have died and the mean survival time was 20 months from the time of diagnosis of RCS. Diagnosis of ocular involvement was made by vitreous biopsy in 56% of cases, enucleation in 13%, and postmortem examination in 31%. The mean age at the time of diagnosis was 60 years. Central nervous system (CNS) involvement was present in 56% of patients, visceral involvement in 16%, and both CNS and visceral involvement in 6%. Isolated ocular disease occurred in 22% of patients. Results of head computed tomography (CT) and cerebrospinal fluid examination more often disclosed evidence of RCS than did body CT or nuclear medicine scans. Responses to treatment were variable, but prognosis for survival is poor.",

keywords = "intraocular tumor, lymphoma, ocular inflammation, reticulum cell sarcoma",

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AU - Freeman, L. Neal

AU - Schachat, Andrew P.

AU - Knox, David L.

AU - Michels, Ronald G.

AU - Green, W. Richard

PY - 1987/1/1

Y1 - 1987/1/1

N2 - The authors report 32 cases of histologically proven ocular reticulum cell sarcoma (RCS). Follow-up data are available for all patients. Twenty-six patients (81%) have died and the mean survival time was 20 months from the time of diagnosis of RCS. Diagnosis of ocular involvement was made by vitreous biopsy in 56% of cases, enucleation in 13%, and postmortem examination in 31%. The mean age at the time of diagnosis was 60 years. Central nervous system (CNS) involvement was present in 56% of patients, visceral involvement in 16%, and both CNS and visceral involvement in 6%. Isolated ocular disease occurred in 22% of patients. Results of head computed tomography (CT) and cerebrospinal fluid examination more often disclosed evidence of RCS than did body CT or nuclear medicine scans. Responses to treatment were variable, but prognosis for survival is poor.

AB - The authors report 32 cases of histologically proven ocular reticulum cell sarcoma (RCS). Follow-up data are available for all patients. Twenty-six patients (81%) have died and the mean survival time was 20 months from the time of diagnosis of RCS. Diagnosis of ocular involvement was made by vitreous biopsy in 56% of cases, enucleation in 13%, and postmortem examination in 31%. The mean age at the time of diagnosis was 60 years. Central nervous system (CNS) involvement was present in 56% of patients, visceral involvement in 16%, and both CNS and visceral involvement in 6%. Isolated ocular disease occurred in 22% of patients. Results of head computed tomography (CT) and cerebrospinal fluid examination more often disclosed evidence of RCS than did body CT or nuclear medicine scans. Responses to treatment were variable, but prognosis for survival is poor.

KW - intraocular tumor

KW - lymphoma

KW - ocular inflammation

KW - reticulum cell sarcoma

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Clinical Features, Laboratory Investigations, and Survival in Ocular Reticulum Cell Sarcoma

Abstract

Keywords

ASJC Scopus subject areas

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