Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2)

Maryna C. Eichelberger, Ellen Sperber, Mariam Wagner, Yasutaka Hoshino, Robert Dudas, Vicki Hodgins, Jennifer Marron, Pamela Nehring, Roberta Casey, Barbara Burns, Ruth Karron, Mary Lou Clements-Mann, Albert Z. Kapikian

Research output: Contribution to journalArticle

Abstract

The safety, infectivity, and immunogenicity of two human-bovine reassortant rotavirus candidate vaccines were evaluated in adults, children, and infants. One of these, Wa x UK, contained a single human rotavirus gene from the Wa strain that encoded VP4 P1A specificity in a background of 10 bovine genes including the VP7 gene that encodes G6 specificity, whereas the other, Wa x (DS-1 x UK), possessed the human rotavirus VP4 gene from the Wa strain as well as the human VP7 gene from strain DS-1 that encoded G2 specificity. Each of these vaccines appeared to be welltolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates.

Original languageEnglish (US)
Pages (from-to)407-416
Number of pages10
JournalJournal of Medical Virology
Volume66
Issue number3
DOIs
StatePublished - Feb 11 2002

Keywords

  • Clinical trials
  • Rotavirus
  • Vaccine

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Eichelberger, M. C., Sperber, E., Wagner, M., Hoshino, Y., Dudas, R., Hodgins, V., Marron, J., Nehring, P., Casey, R., Burns, B., Karron, R., Clements-Mann, M. L., & Kapikian, A. Z. (2002). Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2). Journal of Medical Virology, 66(3), 407-416. https://doi.org/10.1002/jmv.2160