Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2)

Maryna C. Eichelberger, Ellen Sperber, Mariam Wagner, Yasutaka Hoshino, Robert A Dudas, Vicki Hodgins, Jennifer Marron, Pamela Nehring, Roberta Casey, Barbara Burns, Ruth A Karron, Mary Lou Clements-Mann, Albert Z. Kapikian

Research output: Contribution to journalArticle

Abstract

The safety, infectivity, and immunogenicity of two human-bovine reassortant rotavirus candidate vaccines were evaluated in adults, children, and infants. One of these, Wa x UK, contained a single human rotavirus gene from the Wa strain that encoded VP4 P1A specificity in a background of 10 bovine genes including the VP7 gene that encodes G6 specificity, whereas the other, Wa x (DS-1 x UK), possessed the human rotavirus VP4 gene from the Wa strain as well as the human VP7 gene from strain DS-1 that encoded G2 specificity. Each of these vaccines appeared to be welltolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates.

Original languageEnglish (US)
Pages (from-to)407-416
Number of pages10
JournalJournal of Medical Virology
Volume66
Issue number3
DOIs
StatePublished - 2002

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Rotavirus Vaccines
Genes
Rotavirus
Vaccines
UK 1
Safety

Keywords

  • Clinical trials
  • Rotavirus
  • Vaccine

ASJC Scopus subject areas

  • Virology

Cite this

Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2). / Eichelberger, Maryna C.; Sperber, Ellen; Wagner, Mariam; Hoshino, Yasutaka; Dudas, Robert A; Hodgins, Vicki; Marron, Jennifer; Nehring, Pamela; Casey, Roberta; Burns, Barbara; Karron, Ruth A; Clements-Mann, Mary Lou; Kapikian, Albert Z.

In: Journal of Medical Virology, Vol. 66, No. 3, 2002, p. 407-416.

Research output: Contribution to journalArticle

Eichelberger, MC, Sperber, E, Wagner, M, Hoshino, Y, Dudas, RA, Hodgins, V, Marron, J, Nehring, P, Casey, R, Burns, B, Karron, RA, Clements-Mann, ML & Kapikian, AZ 2002, 'Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2)', Journal of Medical Virology, vol. 66, no. 3, pp. 407-416. https://doi.org/10.1002/jmv.2160
Eichelberger, Maryna C. ; Sperber, Ellen ; Wagner, Mariam ; Hoshino, Yasutaka ; Dudas, Robert A ; Hodgins, Vicki ; Marron, Jennifer ; Nehring, Pamela ; Casey, Roberta ; Burns, Barbara ; Karron, Ruth A ; Clements-Mann, Mary Lou ; Kapikian, Albert Z. / Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2). In: Journal of Medical Virology. 2002 ; Vol. 66, No. 3. pp. 407-416.
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