Abstract
The safety, infectivity, and immunogenicity of two human-bovine reassortant rotavirus candidate vaccines were evaluated in adults, children, and infants. One of these, Wa x UK, contained a single human rotavirus gene from the Wa strain that encoded VP4 P1A specificity in a background of 10 bovine genes including the VP7 gene that encodes G6 specificity, whereas the other, Wa x (DS-1 x UK), possessed the human rotavirus VP4 gene from the Wa strain as well as the human VP7 gene from strain DS-1 that encoded G2 specificity. Each of these vaccines appeared to be welltolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 407-416 |
| Number of pages | 10 |
| Journal | Journal of Medical Virology |
| Volume | 66 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2002 |
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Keywords
- Clinical trials
- Rotavirus
- Vaccine
ASJC Scopus subject areas
- Virology
Cite this
Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2). / Eichelberger, Maryna C.; Sperber, Ellen; Wagner, Mariam; Hoshino, Yasutaka; Dudas, Robert A; Hodgins, Vicki; Marron, Jennifer; Nehring, Pamela; Casey, Roberta; Burns, Barbara; Karron, Ruth A; Clements-Mann, Mary Lou; Kapikian, Albert Z.
In: Journal of Medical Virology, Vol. 66, No. 3, 2002, p. 407-416.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2)
AU - Eichelberger, Maryna C.
AU - Sperber, Ellen
AU - Wagner, Mariam
AU - Hoshino, Yasutaka
AU - Dudas, Robert A
AU - Hodgins, Vicki
AU - Marron, Jennifer
AU - Nehring, Pamela
AU - Casey, Roberta
AU - Burns, Barbara
AU - Karron, Ruth A
AU - Clements-Mann, Mary Lou
AU - Kapikian, Albert Z.
PY - 2002
Y1 - 2002
N2 - The safety, infectivity, and immunogenicity of two human-bovine reassortant rotavirus candidate vaccines were evaluated in adults, children, and infants. One of these, Wa x UK, contained a single human rotavirus gene from the Wa strain that encoded VP4 P1A specificity in a background of 10 bovine genes including the VP7 gene that encodes G6 specificity, whereas the other, Wa x (DS-1 x UK), possessed the human rotavirus VP4 gene from the Wa strain as well as the human VP7 gene from strain DS-1 that encoded G2 specificity. Each of these vaccines appeared to be welltolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates.
AB - The safety, infectivity, and immunogenicity of two human-bovine reassortant rotavirus candidate vaccines were evaluated in adults, children, and infants. One of these, Wa x UK, contained a single human rotavirus gene from the Wa strain that encoded VP4 P1A specificity in a background of 10 bovine genes including the VP7 gene that encodes G6 specificity, whereas the other, Wa x (DS-1 x UK), possessed the human rotavirus VP4 gene from the Wa strain as well as the human VP7 gene from strain DS-1 that encoded G2 specificity. Each of these vaccines appeared to be welltolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates.
KW - Clinical trials
KW - Rotavirus
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=0036157292&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036157292&partnerID=8YFLogxK
U2 - 10.1002/jmv.2160
DO - 10.1002/jmv.2160
M3 - Article
C2 - 11793395
AN - SCOPUS:0036157292
VL - 66
SP - 407
EP - 416
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 3
ER -