Abstract
The safety, infectivity, and immunogenicity of two human-bovine reassortant rotavirus candidate vaccines were evaluated in adults, children, and infants. One of these, Wa x UK, contained a single human rotavirus gene from the Wa strain that encoded VP4 P1A specificity in a background of 10 bovine genes including the VP7 gene that encodes G6 specificity, whereas the other, Wa x (DS-1 x UK), possessed the human rotavirus VP4 gene from the Wa strain as well as the human VP7 gene from strain DS-1 that encoded G2 specificity. Each of these vaccines appeared to be welltolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates.
Original language | English (US) |
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Pages (from-to) | 407-416 |
Number of pages | 10 |
Journal | Journal of Medical Virology |
Volume | 66 |
Issue number | 3 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Clinical trials
- Rotavirus
- Vaccine
ASJC Scopus subject areas
- Virology
- Infectious Diseases