Clinical evaluation of 2 point-of-care lateral flow tests for the diagnosis of syphilis

Edith Nakku-Joloba; Agnes Kiragga; Joshua Kimeze Mbazira; Fred Kambugu; Mary Jett-Goheen; Rosalind Parkes Ratanshi; Charlotte Gaydos; Yukari C. Manabe

doi:10.1097/OLQ.0000000000000498

Clinical evaluation of 2 point-of-care lateral flow tests for the diagnosis of syphilis

Edith Nakku-Joloba, Agnes Kiragga, Joshua Kimeze Mbazira, Fred Kambugu, Mary Jett-Goheen, Rosalind Parkes Ratanshi, Charlotte Gaydos, Yukari C. Manabe

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A diagnostic performance study comparing the only Food and Drug Administration-approved, point-of-care (POC) treponemal test (Syphilis Health Check) and the World Health Organization pre-qualified SD Bioline POC treponemal test against a treponemal hemagglutination test (TPHA) and a sequential algorithm of nontreponemal rapid plasma reagin and TPHA found both POC tests had <85% sensitivity compared with the TPHA and <85% sensitivity and <95% specificity compared with the rapid plasma reagin and TPHA standards.

Original language	English (US)
Pages (from-to)	623-625
Number of pages	3
Journal	Sexually transmitted diseases
Volume	43
Issue number	10
DOIs	https://doi.org/10.1097/OLQ.0000000000000498
State	Published - Sep 15 2016

ASJC Scopus subject areas

Dermatology
Public Health, Environmental and Occupational Health
Microbiology (medical)
Infectious Diseases

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abstract = "A diagnostic performance study comparing the only Food and Drug Administration-approved, point-of-care (POC) treponemal test (Syphilis Health Check) and the World Health Organization pre-qualified SD Bioline POC treponemal test against a treponemal hemagglutination test (TPHA) and a sequential algorithm of nontreponemal rapid plasma reagin and TPHA found both POC tests had <85% sensitivity compared with the TPHA and <85% sensitivity and <95% specificity compared with the rapid plasma reagin and TPHA standards.",

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AU - Jett-Goheen, Mary

AU - Ratanshi, Rosalind Parkes

AU - Gaydos, Charlotte

AU - Manabe, Yukari C.

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AB - A diagnostic performance study comparing the only Food and Drug Administration-approved, point-of-care (POC) treponemal test (Syphilis Health Check) and the World Health Organization pre-qualified SD Bioline POC treponemal test against a treponemal hemagglutination test (TPHA) and a sequential algorithm of nontreponemal rapid plasma reagin and TPHA found both POC tests had <85% sensitivity compared with the TPHA and <85% sensitivity and <95% specificity compared with the rapid plasma reagin and TPHA standards.

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Clinical evaluation of 2 point-of-care lateral flow tests for the diagnosis of syphilis

Abstract

ASJC Scopus subject areas

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