Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study

Diego J. Maselli; Surya P. Bhatt; Antonio Anzueto; Russell P. Bowler; Dawn L. DeMeo; Alejandro A. Diaz; Mark T. Dransfield; Ashraf Fawzy; Marilyn G. Foreman; Nicola A. Hanania; Craig P. Hersh; Victor Kim; Gregory L. Kinney; Nirupama Putcha; Emily S. Wan; J. Michael Wells; Gloria E. Westney; Kendra A. Young; Edwin K. Silverman; Mei Lan K. Han; Barry J. Make

doi:10.1016/j.chest.2019.04.135

Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study

Diego J. Maselli, Surya P. Bhatt, Antonio Anzueto, Russell P. Bowler, Dawn L. DeMeo, Alejandro A. Diaz, Mark T. Dransfield, Ashraf Fawzy, Marilyn G. Foreman, Nicola A. Hanania, Craig P. Hersh, Victor Kim, Gregory L. Kinney, Nirupama Putcha, Emily S. Wan, J. Michael Wells, Gloria E. Westney, Kendra A. Young, Edwin K. Silverman, Mei Lan K. HanBarry J. Make

School of Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter, longitudinal analysis of > 10,000 subjects, including smokers with a ≥ 10 pack-year history with and without COPD and healthy never smokers. The goal was to characterize disease-related phenotypes and explore associations with susceptibility genes. The subjects were extensively phenotyped with the use of comprehensive symptom and comorbidity questionnaires, spirometry, CT scans of the chest, and genetic and biomarker profiling. The objective of this review was to summarize the major advances in the clinical epidemiology of COPD from the first 10 years of the COPDGene study. We highlight the influence of age, sex, and race on the natural history of COPD, and the impact of comorbid conditions, chronic bronchitis, exacerbations, and asthma/COPD overlap.

Original language	English (US)
Pages (from-to)	228-238
Number of pages	11
Journal	CHEST
Volume	156
Issue number	2
DOIs	https://doi.org/10.1016/j.chest.2019.04.135
State	Published - Aug 2019

Keywords

COPD
COPDGene
chronic bronchitis
comorbidities
epidemiology
sex

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.chest.2019.04.135

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Maselli, D. J., Bhatt, S. P., Anzueto, A., Bowler, R. P., DeMeo, D. L., Diaz, A. A., Dransfield, M. T., Fawzy, A., Foreman, M. G., Hanania, N. A., Hersh, C. P., Kim, V., Kinney, G. L., Putcha, N., Wan, E. S., Wells, J. M., Westney, G. E., Young, K. A., Silverman, E. K., ... Make, B. J. (2019). Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study. CHEST, 156(2), 228-238. https://doi.org/10.1016/j.chest.2019.04.135

Maselli, DJ, Bhatt, SP, Anzueto, A, Bowler, RP, DeMeo, DL, Diaz, AA, Dransfield, MT, Fawzy, A, Foreman, MG, Hanania, NA, Hersh, CP, Kim, V, Kinney, GL, Putcha, N, Wan, ES, Wells, JM, Westney, GE, Young, KA, Silverman, EK, Han, MLK & Make, BJ 2019, 'Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study', CHEST, vol. 156, no. 2, pp. 228-238. https://doi.org/10.1016/j.chest.2019.04.135

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title = "Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study",

abstract = "The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter, longitudinal analysis of > 10,000 subjects, including smokers with a ≥ 10 pack-year history with and without COPD and healthy never smokers. The goal was to characterize disease-related phenotypes and explore associations with susceptibility genes. The subjects were extensively phenotyped with the use of comprehensive symptom and comorbidity questionnaires, spirometry, CT scans of the chest, and genetic and biomarker profiling. The objective of this review was to summarize the major advances in the clinical epidemiology of COPD from the first 10 years of the COPDGene study. We highlight the influence of age, sex, and race on the natural history of COPD, and the impact of comorbid conditions, chronic bronchitis, exacerbations, and asthma/COPD overlap.",

keywords = "COPD, COPDGene, chronic bronchitis, comorbidities, epidemiology, sex",

author = "Maselli, {Diego J.} and Bhatt, {Surya P.} and Antonio Anzueto and Bowler, {Russell P.} and DeMeo, {Dawn L.} and Diaz, {Alejandro A.} and Dransfield, {Mark T.} and Ashraf Fawzy and Foreman, {Marilyn G.} and Hanania, {Nicola A.} and Hersh, {Craig P.} and Victor Kim and Kinney, {Gregory L.} and Nirupama Putcha and Wan, {Emily S.} and Wells, {J. Michael} and Westney, {Gloria E.} and Young, {Kendra A.} and Silverman, {Edwin K.} and Han, {Mei Lan K.} and Make, {Barry J.}",

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year = "2019",

month = aug,

doi = "10.1016/j.chest.2019.04.135",

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AU - Maselli, Diego J.

AU - Bhatt, Surya P.

AU - Anzueto, Antonio

AU - Bowler, Russell P.

AU - DeMeo, Dawn L.

AU - Diaz, Alejandro A.

AU - Dransfield, Mark T.

AU - Fawzy, Ashraf

AU - Foreman, Marilyn G.

AU - Hanania, Nicola A.

AU - Hersh, Craig P.

AU - Kim, Victor

AU - Kinney, Gregory L.

AU - Putcha, Nirupama

AU - Wan, Emily S.

AU - Wells, J. Michael

AU - Westney, Gloria E.

AU - Young, Kendra A.

AU - Silverman, Edwin K.

AU - Han, Mei Lan K.

AU - Make, Barry J.

PY - 2019/8

Y1 - 2019/8

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KW - chronic bronchitis

KW - comorbidities

KW - epidemiology

KW - sex

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Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study

Abstract

Keywords

ASJC Scopus subject areas

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