Clinical course of oxaliplatin-induced neuropathy

Results from the randomized phase III trial N08CB (Alliance)

Deirdre R. Pachman, Rui Qin, Drew K. Seisler, Ellen M L Smith, Andreas S. Beutler, Lauren E. Ta, Jacqueline M. Lafky, Nina Wagner-Johnston, Kathryn J. Ruddy, Shaker Dakhil, Nathan P. Staff, Axel Grothey, Charles L. Loprinzi

Research output: Contribution to journalArticle

Abstract

Purpose: Given that the clinical course of oxaliplatin-induced neuropathy is not well defined, the current study was performed to better understand clinical parameters associated with its presentation Methods: Acute and chronic neuropathy was evaluated in patients receiving adjuvant FOLFOX (fluorouracil, leucovorin, and oxaliplatin) on study N08CB (North Central Cancer Treatment Group, Alliance) Acute neuropathy was assessed by having patients complete daily questionnaires for 6 days with each cycle of FOLFOX. Before each dose of FOLFOX and as long as 18 months after chemotherapy cessation, chronic neurotoxicity was assessed with use of the 20-item, European Organisation for Research and Treatment of Cancer quality-of-life questionnaire for patients with chemotherapy-induced peripheral neuropathy. Results: Three hundred eight (89%) of the 346 patients had at least one symptom of acute neuropathy with the first cycle of FOLFOX; these symptoms included sensitivity to touching cold items (71%), sensitivity to swallowing cold items (71%), throat discomfort (63%), or muscle cramps (42%) Acute symptoms peaked at day 3 and improved, although they did not always resolve completely between treatments. These symptoms were about twice as severe in cycles 2 through 12 as they were in cycle 1. For chronic neurotoxicity, tingling was the most severe symptom, followed by numbness and then pain. During chemotherapy, symptoms in the hands were more prominent than they were in the feet; by 18 months, symptoms were more severe in the feet than they were in the hands. Patients with more severe acute neuropathy during the first cycle of therapy experienced more chronic sensory neurotoxicity (P <.0001) Conclusion: Acute oxaliplatin-induced neuropathy symptoms do not always completely resolve between treatment cycles and are only half as severe on the first cycle as compared with subsequent cycles. There is a correlation between the severities of acute and chronic neuropathies.

Original languageEnglish (US)
Pages (from-to)3416-3422
Number of pages7
JournalJournal of Clinical Oncology
Volume33
Issue number30
DOIs
StatePublished - Oct 20 2015
Externally publishedYes

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oxaliplatin
Drug Therapy
Foot
Hand
Muscle Cramp
Leucovorin
Hypesthesia
Peripheral Nervous System Diseases
Therapeutics
Deglutition
Pharynx
Fluorouracil
Quality of Life
Pain

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pachman, D. R., Qin, R., Seisler, D. K., Smith, E. M. L., Beutler, A. S., Ta, L. E., ... Loprinzi, C. L. (2015). Clinical course of oxaliplatin-induced neuropathy: Results from the randomized phase III trial N08CB (Alliance). Journal of Clinical Oncology, 33(30), 3416-3422. https://doi.org/10.1200/JCO.2014.58.8533

Clinical course of oxaliplatin-induced neuropathy : Results from the randomized phase III trial N08CB (Alliance). / Pachman, Deirdre R.; Qin, Rui; Seisler, Drew K.; Smith, Ellen M L; Beutler, Andreas S.; Ta, Lauren E.; Lafky, Jacqueline M.; Wagner-Johnston, Nina; Ruddy, Kathryn J.; Dakhil, Shaker; Staff, Nathan P.; Grothey, Axel; Loprinzi, Charles L.

In: Journal of Clinical Oncology, Vol. 33, No. 30, 20.10.2015, p. 3416-3422.

Research output: Contribution to journalArticle

Pachman, DR, Qin, R, Seisler, DK, Smith, EML, Beutler, AS, Ta, LE, Lafky, JM, Wagner-Johnston, N, Ruddy, KJ, Dakhil, S, Staff, NP, Grothey, A & Loprinzi, CL 2015, 'Clinical course of oxaliplatin-induced neuropathy: Results from the randomized phase III trial N08CB (Alliance)', Journal of Clinical Oncology, vol. 33, no. 30, pp. 3416-3422. https://doi.org/10.1200/JCO.2014.58.8533
Pachman, Deirdre R. ; Qin, Rui ; Seisler, Drew K. ; Smith, Ellen M L ; Beutler, Andreas S. ; Ta, Lauren E. ; Lafky, Jacqueline M. ; Wagner-Johnston, Nina ; Ruddy, Kathryn J. ; Dakhil, Shaker ; Staff, Nathan P. ; Grothey, Axel ; Loprinzi, Charles L. / Clinical course of oxaliplatin-induced neuropathy : Results from the randomized phase III trial N08CB (Alliance). In: Journal of Clinical Oncology. 2015 ; Vol. 33, No. 30. pp. 3416-3422.
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abstract = "Purpose: Given that the clinical course of oxaliplatin-induced neuropathy is not well defined, the current study was performed to better understand clinical parameters associated with its presentation Methods: Acute and chronic neuropathy was evaluated in patients receiving adjuvant FOLFOX (fluorouracil, leucovorin, and oxaliplatin) on study N08CB (North Central Cancer Treatment Group, Alliance) Acute neuropathy was assessed by having patients complete daily questionnaires for 6 days with each cycle of FOLFOX. Before each dose of FOLFOX and as long as 18 months after chemotherapy cessation, chronic neurotoxicity was assessed with use of the 20-item, European Organisation for Research and Treatment of Cancer quality-of-life questionnaire for patients with chemotherapy-induced peripheral neuropathy. Results: Three hundred eight (89{\%}) of the 346 patients had at least one symptom of acute neuropathy with the first cycle of FOLFOX; these symptoms included sensitivity to touching cold items (71{\%}), sensitivity to swallowing cold items (71{\%}), throat discomfort (63{\%}), or muscle cramps (42{\%}) Acute symptoms peaked at day 3 and improved, although they did not always resolve completely between treatments. These symptoms were about twice as severe in cycles 2 through 12 as they were in cycle 1. For chronic neurotoxicity, tingling was the most severe symptom, followed by numbness and then pain. During chemotherapy, symptoms in the hands were more prominent than they were in the feet; by 18 months, symptoms were more severe in the feet than they were in the hands. Patients with more severe acute neuropathy during the first cycle of therapy experienced more chronic sensory neurotoxicity (P <.0001) Conclusion: Acute oxaliplatin-induced neuropathy symptoms do not always completely resolve between treatment cycles and are only half as severe on the first cycle as compared with subsequent cycles. There is a correlation between the severities of acute and chronic neuropathies.",
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AU - Smith, Ellen M L

AU - Beutler, Andreas S.

AU - Ta, Lauren E.

AU - Lafky, Jacqueline M.

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AU - Ruddy, Kathryn J.

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AU - Grothey, Axel

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