Clinical correlation between CEA and breast cancer

D. C. Tormey, T. P. Waalkes

Research output: Contribution to journalArticle

Abstract

Elevated plasma CEA levels were observed in 14.2% (2/14) of preoperative patients. 7.9% (3/38) of postoperative patients, and 70.9% (83/117) of patients with metastatic disease. Within these respective groups the simultaneous measurement of hCG, 3 polyamines and 3 minor nucleosides further enhanced the detection rates to 69.2%, 54.2% and 98.6%. It was observed that in patients with at least 1 elevated CEA, measurement of sequential CEA levels paralleled the clinical course of metastatic disease in 25 patients. Prior to therapy for metastatic disease CEA levels > 5 ng/ml were associated with lower response rates and a shorter time to treatment failure than were levels ≤5 ng/ml. This effect was enhanced in patients also having an elevated hCG level. Hepatic and osseous involvement were associated with a greater incidence of CEA elevations than were pulmonary or soft tissue sites of involvement.

Original languageEnglish (US)
Pages (from-to)1507-1511
Number of pages5
JournalCancer
Volume42
Issue number3 . SUPPL.
StatePublished - 1978

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Breast Neoplasms
Polyamines
Treatment Failure
Nucleosides
Lung
Liver
Incidence
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tormey, D. C., & Waalkes, T. P. (1978). Clinical correlation between CEA and breast cancer. Cancer, 42(3 . SUPPL.), 1507-1511.

Clinical correlation between CEA and breast cancer. / Tormey, D. C.; Waalkes, T. P.

In: Cancer, Vol. 42, No. 3 . SUPPL., 1978, p. 1507-1511.

Research output: Contribution to journalArticle

Tormey, DC & Waalkes, TP 1978, 'Clinical correlation between CEA and breast cancer', Cancer, vol. 42, no. 3 . SUPPL., pp. 1507-1511.
Tormey DC, Waalkes TP. Clinical correlation between CEA and breast cancer. Cancer. 1978;42(3 . SUPPL.):1507-1511.
Tormey, D. C. ; Waalkes, T. P. / Clinical correlation between CEA and breast cancer. In: Cancer. 1978 ; Vol. 42, No. 3 . SUPPL. pp. 1507-1511.
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