TY - JOUR
T1 - Clinical correlates of tuberculosis co-infection in HIV-infected children hospitalized in Peru
AU - Ramírez-Cardich, María E.
AU - Kawai, Vivian
AU - Oberhelman, Richard A.
AU - Bautista, Christian T.
AU - Castillo, María E.
AU - Gilman, Robert H.
N1 - Funding Information:
This study was supported in part by the following grants: National Institutes of Health 1 RO1 AI-49139, USAID – Tuberculosis Award HRN-5986-A-00-6006-00, NIH ITREID grant 5D43-TW00910, the Fogarty-NIH AIDS training program 3T22-TW00016-05S3, and the NIAID tutorial training grant 5T35-AI07646-02. The authors wish to thank Mirko Zimic for statistical support, Luz Caviedes for processing MTB cultures, and Gloria Chauca for contributing flow cytometry testing.
PY - 2006/7
Y1 - 2006/7
N2 - Introduction: In developing countries, tuberculosis (TB) is responsible for almost 250 000 deaths among children yearly. Active TB in children with human immunodeficiency virus (HIV) infection is difficult to diagnose and progresses rapidly to death. The aim of this preliminary study was to investigate the prevalence and clinical correlates of TB-related illness among HIV-infected children admitted to an infectious diseases ward in Peru, a country where TB is highly endemic. Method: Forty-seven HIV-infected children admitted for a suspected infectious process in a Peruvian hospital were investigated for evidence of clinical tuberculosis by auramine stain, culture, and polymerase chain reaction (PCR) of clinical specimens. Results: Eight children (17%) had evidence of tuberculosis, including five with positive cultures and three with positive PCR tests only. Weight loss was the only feature associated with a positive test for tuberculosis. Radiological changes were very common in both TB-positive and TB-negative groups and these changes were not useful to identify TB-positive cases. Conclusions: Weight loss may be used to identify high-risk HIV positive children who require more aggressive evaluation for tuberculosis. Radiological changes were common in both TB-positive and TB-negative groups.
AB - Introduction: In developing countries, tuberculosis (TB) is responsible for almost 250 000 deaths among children yearly. Active TB in children with human immunodeficiency virus (HIV) infection is difficult to diagnose and progresses rapidly to death. The aim of this preliminary study was to investigate the prevalence and clinical correlates of TB-related illness among HIV-infected children admitted to an infectious diseases ward in Peru, a country where TB is highly endemic. Method: Forty-seven HIV-infected children admitted for a suspected infectious process in a Peruvian hospital were investigated for evidence of clinical tuberculosis by auramine stain, culture, and polymerase chain reaction (PCR) of clinical specimens. Results: Eight children (17%) had evidence of tuberculosis, including five with positive cultures and three with positive PCR tests only. Weight loss was the only feature associated with a positive test for tuberculosis. Radiological changes were very common in both TB-positive and TB-negative groups and these changes were not useful to identify TB-positive cases. Conclusions: Weight loss may be used to identify high-risk HIV positive children who require more aggressive evaluation for tuberculosis. Radiological changes were common in both TB-positive and TB-negative groups.
KW - Children
KW - HIV
KW - Peru
KW - Tuberculosis
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U2 - 10.1016/j.ijid.2005.06.012
DO - 10.1016/j.ijid.2005.06.012
M3 - Article
C2 - 16540360
AN - SCOPUS:33745013084
SN - 1201-9712
VL - 10
SP - 278
EP - 281
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
IS - 4
ER -