Clinical correlates of tuberculosis co-infection in HIV-infected children hospitalized in Peru

María E. Ramírez-Cardich, Vivian Kawai, Richard A. Oberhelman, Christian T. Bautista, María E. Castillo, Robert H. Gilman

Research output: Contribution to journalArticle

Abstract

Introduction: In developing countries, tuberculosis (TB) is responsible for almost 250 000 deaths among children yearly. Active TB in children with human immunodeficiency virus (HIV) infection is difficult to diagnose and progresses rapidly to death. The aim of this preliminary study was to investigate the prevalence and clinical correlates of TB-related illness among HIV-infected children admitted to an infectious diseases ward in Peru, a country where TB is highly endemic. Method: Forty-seven HIV-infected children admitted for a suspected infectious process in a Peruvian hospital were investigated for evidence of clinical tuberculosis by auramine stain, culture, and polymerase chain reaction (PCR) of clinical specimens. Results: Eight children (17%) had evidence of tuberculosis, including five with positive cultures and three with positive PCR tests only. Weight loss was the only feature associated with a positive test for tuberculosis. Radiological changes were very common in both TB-positive and TB-negative groups and these changes were not useful to identify TB-positive cases. Conclusions: Weight loss may be used to identify high-risk HIV positive children who require more aggressive evaluation for tuberculosis. Radiological changes were common in both TB-positive and TB-negative groups.

Original languageEnglish (US)
Pages (from-to)278-281
Number of pages4
JournalInternational Journal of Infectious Diseases
Volume10
Issue number4
DOIs
StatePublished - Jul 1 2006

Keywords

  • Children
  • HIV
  • Peru
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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