Clinical correlates of lateral ventricular enlargement in bipolar affective disorder

G. D. Pearlson, D. J. Garbacz, R. H. Tompkins, H. S. Ahn, D. F. Gutterman, A. E. Veroff, J. R. DePaulo

    Research output: Contribution to journalArticlepeer-review

    63 Scopus citations


    The presence of lateral ventricular enlargement in some manic-depressive subjects, as assessed by ventricular-brain ratios (VBRs), has been reported. A study of 27 bipolar patients and 27 individually matched normal controls confirmed that finding. Bipolar patients had significantly larger VBRs than did controls. Clinical measures associated with the presence of ventricular enlargement in the bipolar patients included more frequent hospitalizations and histories of persistent unemployment. Other measures of illness severity or social deterioration were not significantly associated with large VBR.

    Original languageEnglish (US)
    Pages (from-to)253-256
    Number of pages4
    JournalAmerican Journal of Psychiatry
    Issue number2
    StatePublished - Jan 1 1984

    ASJC Scopus subject areas

    • Psychiatry and Mental health


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