TY - JOUR
T1 - Clinical Correlates of Dementia and Disability in Huntington's Disease*
AU - Brandt, Jason
AU - Strauss, Milton E.
AU - Larus, John
AU - Jensen, Barbara
AU - Folstein, Susan E.
AU - Folstein, Marshal F.
N1 - Funding Information:
* This research was supported in part by Grant No. 5PO1 NS16375-03, Grant No. RR00722 OPD-CRC, and BRSG Grant No. 2S07 RR07041-16, all from the National Institutes of Health. Preparation of this manuscript was supported in part by NIMH Grant No. lROl MH38387-01 to the Johns Hopkins University. The contributions of Dr. Amy Veroff, Ms. Thelma Knotts, and Ms. Karen Reynolds to the conduct of this research are gratefully acknowledged. We thank the anonymous reviewers for their helpful comments and Ms. Bozena Lamparski for typing the manuscript. Address correspondence to: Jason Brandt, Ph.D., Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA. Accepted for publication: January 13, 1984.
PY - 1984/11/1
Y1 - 1984/11/1
N2 - The relationship of duration of illness and severity of neurological impairment to psychometric performance and activities of daily living was examined in 57 patients with Huntington's Disease (HD), As earlier studies suggested, a distinct cognitive profile characterized patients early in the disease. Duration of symptoms, however, proved to be a weaker correlate of cognitive decline than was motor impairment at the time of testing. For predicting adaptive functioning, both duration of symptoms and neurological status were important variables. This study underscores the limitations of length of illness as a classificatory variable in studies of dementia in HD. We further suggest that future studies consider the contribution of defects in precise timing and sequential operations to the cognitive and adaptive deficits of these patients.
AB - The relationship of duration of illness and severity of neurological impairment to psychometric performance and activities of daily living was examined in 57 patients with Huntington's Disease (HD), As earlier studies suggested, a distinct cognitive profile characterized patients early in the disease. Duration of symptoms, however, proved to be a weaker correlate of cognitive decline than was motor impairment at the time of testing. For predicting adaptive functioning, both duration of symptoms and neurological status were important variables. This study underscores the limitations of length of illness as a classificatory variable in studies of dementia in HD. We further suggest that future studies consider the contribution of defects in precise timing and sequential operations to the cognitive and adaptive deficits of these patients.
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U2 - 10.1080/01688638408401231
DO - 10.1080/01688638408401231
M3 - Article
C2 - 6238979
AN - SCOPUS:0021722327
SN - 0165-0475
VL - 6
SP - 401
EP - 412
JO - Journal of Clinical Neuropsychology
JF - Journal of Clinical Neuropsychology
IS - 4
ER -