Clinical correlates of decreased anteroposterior metabolic gradients in positron emission tomography (PET) of schizophrenic patients

L. E. DeLisi, M. S. Buchsbaum, H. H. Holcomb, S. Dowling-Zimmerman, D. Pickar, J. Boronow, J. M. Morihisa, D. P. van Kammen, W. Carpenter, R. Kessler

Research output: Contribution to journalArticle

Abstract

The finding in schizophrenic patients of a reversal of the normal frontal to posterior pattern of brain metabolic activity with positron emission tomography (PET) is of interest, but its relevance to psychopathology is unknown. Using PET, the authors studied 21 patients with chronic schizophrenia and 21 age- and sex-matched control subjects. Although eight of the 21 patients and only one of the control subjects showed a relatively lower anteroposterior metabolic gradient, no clinical correlates of this finding were noted. In addition, cerebral atrophy, as determined by CAT scan, was not associated with this aberrant metabolic pattern.

Original languageEnglish (US)
Pages (from-to)78-81
Number of pages4
JournalAmerican Journal of Psychiatry
Volume142
Issue number1
StatePublished - 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

DeLisi, L. E., Buchsbaum, M. S., Holcomb, H. H., Dowling-Zimmerman, S., Pickar, D., Boronow, J., Morihisa, J. M., van Kammen, D. P., Carpenter, W., & Kessler, R. (1985). Clinical correlates of decreased anteroposterior metabolic gradients in positron emission tomography (PET) of schizophrenic patients. American Journal of Psychiatry, 142(1), 78-81.