Clinical comparison of technetium-99m-EC, technetium-99m-MAG3 and iodine- 131-OIH in renal disorders

L. Kabasakal, H. T. Turoglu, C. Onsel, K. Ozker, I. Uslu, S. Atay, T. Cansiz, K. Sonmezoglu, E. Altiok, A. T. Isitman, T. Kapicioglu, I. Urgancioglu

Research output: Contribution to journalArticle

Abstract

Technetium-99m-ethylenedicysteine has recently been developed for renal function studies. The pharmacokinetics of 99mTc-EC were studied by constant infusion technique and compared with 99mTc-MAG3 and 131I-OIH in 11 patients with various renal disorders. Methods: After giving a 7.4 MBq 131I-OIH and 90-110 MBq 99mTc-EC or 99mTc-MAG3 bolus, a constant infusion (1MBq/ml 99mTc-agent and 0.07 MBq/m 131I-OIH was started. Sixteen blood and five urine samples were obtained over three hr. Results: The renal clearance of 99mTc-EC was higher than that of 99mTc-MAG3. The 99mTc-EC/OIH and 99mTC-MAG3/OIH ratios were 0.75 ± 0.05 and 0.55 ± 0.10 (p = 0.00087), respectively. The distribution volume of 99mTc-EC was also higher than that of 99mTc-MAG3 (15722 ± 4644 and 9509 ± 2788 ml/1.73m2, respectively; p = 0.072). The 99mTc-EC/OIH and 99mTc- MAG3/OIH distribution volume ratios were 1.03 ± 0.14 and 0.55 ± 0.10, respectively (p = 0.0003). The 60-min excretion values of 99mTc-EC and 99mTc-MAG3 were compared to that of OIH. The 99mTc-EC/OIH and 99mTc- MAG3/OIH excretion ratios were 0.96 ± 0.06 and 1.07 ± 0.10, respectively (p = 0.162). The protein binding of 99mTc-EC and OIH were found to be 34% ± 4 and 66% ± 5, respectively (p < 0.0001). The red cell binding of 99mTC- EC was negligible (3% ± 1.2) in comparison to OIH (27% ± 3; p < 0.0001). Conclusion: This limited study demonstrates the pharmacokinetic and renal clearance properties of 99mTc-EC. This agent has good potential for renal function evaluation.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalJournal of Nuclear Medicine
Volume36
Issue number2
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Kabasakal, L., Turoglu, H. T., Onsel, C., Ozker, K., Uslu, I., Atay, S., Cansiz, T., Sonmezoglu, K., Altiok, E., Isitman, A. T., Kapicioglu, T., & Urgancioglu, I. (1995). Clinical comparison of technetium-99m-EC, technetium-99m-MAG3 and iodine- 131-OIH in renal disorders. Journal of Nuclear Medicine, 36(2), 224-228.