Clinical Chemistry of Patients with Ebola in Monrovia, Liberia

Emmie De Wit; Shelby Kramer; Joseph Prescott; Kyle Rosenke; Darryl Falzarano; Andrea Marzi; Robert J. Fischer; David Safronetz; Thomas Hoenen; Allison Groseth; Neeltje Van Doremalen; Trenton Bushmaker; Kristin L. McNally; Friederike Feldmann; Brandi N. Williamson; Sonja M. Best; Hideki Ebihara; Igor A.C. Damiani; Brett Adamson; Kathryn C. Zoon; Tolbert G. Nyenswah; Fatorma K. Bolay; Moses Massaquoi; Armand Sprecher; Heinz Feldmann; Vincent J. Munster

doi:10.1093/infdis/jiw187

Clinical Chemistry of Patients with Ebola in Monrovia, Liberia

Emmie De Wit, Shelby Kramer, Joseph Prescott, Kyle Rosenke, Darryl Falzarano, Andrea Marzi, Robert J. Fischer, David Safronetz, Thomas Hoenen, Allison Groseth, Neeltje Van Doremalen, Trenton Bushmaker, Kristin L. McNally, Friederike Feldmann, Brandi N. Williamson, Sonja M. Best, Hideki Ebihara, Igor A.C. Damiani, Brett Adamson, Kathryn C. ZoonTolbert G. Nyenswah, Fatorma K. Bolay, Moses Massaquoi, Armand Sprecher, Heinz Feldmann, Vincent J. Munster

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eternal Love Winning Africa (ELWA) outbreak diagnostic laboratory, established in Monrovia, Liberia, to provide Ebola virus and Plasmodium spp. diagnostics during the Ebola epidemic, implemented clinical chemistry analyzers in December 2014. Clinical chemistry testing was performed for 68 patients in triage, including 12 patients infected with Ebola virus and 18 infected with Plasmodium spp. The main distinguishing feature in clinical chemistry of Ebola virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase levels and the decrease in calcium. The implementation of clinical chemistry is probably most helpful when the medical supportive care implemented at the Ebola treatment unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers can be used to monitor electrolyte balance.

Original language	English (US)
Pages (from-to)	S303-S307
Journal	Journal of Infectious Diseases
Volume	214
DOIs	https://doi.org/10.1093/infdis/jiw187
State	Published - Oct 15 2016
Externally published	Yes

Keywords

Clinical chemistry
Ebola virus
West Africa

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jiw187

Cite this

De Wit, E., Kramer, S., Prescott, J., Rosenke, K., Falzarano, D., Marzi, A., Fischer, R. J., Safronetz, D., Hoenen, T., Groseth, A., Van Doremalen, N., Bushmaker, T., McNally, K. L., Feldmann, F., Williamson, B. N., Best, S. M., Ebihara, H., Damiani, I. A. C., Adamson, B., ... Munster, V. J. (2016). Clinical Chemistry of Patients with Ebola in Monrovia, Liberia. Journal of Infectious Diseases, 214, S303-S307. https://doi.org/10.1093/infdis/jiw187

De Wit, E, Kramer, S, Prescott, J, Rosenke, K, Falzarano, D, Marzi, A, Fischer, RJ, Safronetz, D, Hoenen, T, Groseth, A, Van Doremalen, N, Bushmaker, T, McNally, KL, Feldmann, F, Williamson, BN, Best, SM, Ebihara, H, Damiani, IAC, Adamson, B, Zoon, KC, Nyenswah, TG, Bolay, FK, Massaquoi, M, Sprecher, A, Feldmann, H & Munster, VJ 2016, 'Clinical Chemistry of Patients with Ebola in Monrovia, Liberia', Journal of Infectious Diseases, vol. 214, pp. S303-S307. https://doi.org/10.1093/infdis/jiw187

@article{e6b4770498cd46bfa028beaaec27609b,

title = "Clinical Chemistry of Patients with Ebola in Monrovia, Liberia",

abstract = "The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eternal Love Winning Africa (ELWA) outbreak diagnostic laboratory, established in Monrovia, Liberia, to provide Ebola virus and Plasmodium spp. diagnostics during the Ebola epidemic, implemented clinical chemistry analyzers in December 2014. Clinical chemistry testing was performed for 68 patients in triage, including 12 patients infected with Ebola virus and 18 infected with Plasmodium spp. The main distinguishing feature in clinical chemistry of Ebola virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase levels and the decrease in calcium. The implementation of clinical chemistry is probably most helpful when the medical supportive care implemented at the Ebola treatment unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers can be used to monitor electrolyte balance.",

keywords = "Clinical chemistry, Ebola virus, West Africa",

author = "{De Wit}, Emmie and Shelby Kramer and Joseph Prescott and Kyle Rosenke and Darryl Falzarano and Andrea Marzi and Fischer, {Robert J.} and David Safronetz and Thomas Hoenen and Allison Groseth and {Van Doremalen}, Neeltje and Trenton Bushmaker and McNally, {Kristin L.} and Friederike Feldmann and Williamson, {Brandi N.} and Best, {Sonja M.} and Hideki Ebihara and Damiani, {Igor A.C.} and Brett Adamson and Zoon, {Kathryn C.} and Nyenswah, {Tolbert G.} and Bolay, {Fatorma K.} and Moses Massaquoi and Armand Sprecher and Heinz Feldmann and Munster, {Vincent J.}",

note = "Publisher Copyright: {\textcopyright} 2016 Published by Oxford University Press for the Infectious Diseases Society of America 2016.",

year = "2016",

month = oct,

day = "15",

doi = "10.1093/infdis/jiw187",

language = "English (US)",

volume = "214",

pages = "S303--S307",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

}

TY - JOUR

T1 - Clinical Chemistry of Patients with Ebola in Monrovia, Liberia

AU - De Wit, Emmie

AU - Kramer, Shelby

AU - Prescott, Joseph

AU - Rosenke, Kyle

AU - Falzarano, Darryl

AU - Marzi, Andrea

AU - Fischer, Robert J.

AU - Safronetz, David

AU - Hoenen, Thomas

AU - Groseth, Allison

AU - Van Doremalen, Neeltje

AU - Bushmaker, Trenton

AU - McNally, Kristin L.

AU - Feldmann, Friederike

AU - Williamson, Brandi N.

AU - Best, Sonja M.

AU - Ebihara, Hideki

AU - Damiani, Igor A.C.

AU - Adamson, Brett

AU - Zoon, Kathryn C.

AU - Nyenswah, Tolbert G.

AU - Bolay, Fatorma K.

AU - Massaquoi, Moses

AU - Sprecher, Armand

AU - Feldmann, Heinz

AU - Munster, Vincent J.

PY - 2016/10/15

Y1 - 2016/10/15

N2 - The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eternal Love Winning Africa (ELWA) outbreak diagnostic laboratory, established in Monrovia, Liberia, to provide Ebola virus and Plasmodium spp. diagnostics during the Ebola epidemic, implemented clinical chemistry analyzers in December 2014. Clinical chemistry testing was performed for 68 patients in triage, including 12 patients infected with Ebola virus and 18 infected with Plasmodium spp. The main distinguishing feature in clinical chemistry of Ebola virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase levels and the decrease in calcium. The implementation of clinical chemistry is probably most helpful when the medical supportive care implemented at the Ebola treatment unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers can be used to monitor electrolyte balance.

AB - The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eternal Love Winning Africa (ELWA) outbreak diagnostic laboratory, established in Monrovia, Liberia, to provide Ebola virus and Plasmodium spp. diagnostics during the Ebola epidemic, implemented clinical chemistry analyzers in December 2014. Clinical chemistry testing was performed for 68 patients in triage, including 12 patients infected with Ebola virus and 18 infected with Plasmodium spp. The main distinguishing feature in clinical chemistry of Ebola virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase levels and the decrease in calcium. The implementation of clinical chemistry is probably most helpful when the medical supportive care implemented at the Ebola treatment unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers can be used to monitor electrolyte balance.

KW - Clinical chemistry

KW - Ebola virus

KW - West Africa

UR - http://www.scopus.com/inward/record.url?scp=84990938538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990938538&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiw187

DO - 10.1093/infdis/jiw187

M3 - Article

C2 - 27471319

AN - SCOPUS:84990938538

SN - 0022-1899

VL - 214

SP - S303-S307

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

ER -

Clinical Chemistry of Patients with Ebola in Monrovia, Liberia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this