Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study

Robert Bain, Rebecca Cosgriff, Marco Zampoli, Alexander Elbert, Pierre Régis Burgel, Siobhán B. Carr, Claudio Castaños, Carla Colombo, Harriet Corvol, Albert Faro, Christopher H. Goss, Hector Gutierrez, Andreas Jung, Nataliya Kashirskaya, Bruce C. Marshall, Joel Melo, Pedro Mondejar-Lopez, Isabelle de Monestrol, Lutz Naehrlich, Rita PadoanMaria Dolores Pastor-Vivero, Samar Rizvi, Marco Salvatore, Luiz Vicente Ribeiro Ferreira da Silva Filho, Keith G. Brownlee, Iram J. Haq, Malcolm Brodlie

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The presence of co-morbidities, including underlying respiratory problems, has been identified as a risk factor for severe COVID-19 disease. Information on the clinical course of SARS-CoV-2 infection in children with cystic fibrosis (CF) is limited, yet vital to provide accurate advice for children with CF, their families, caregivers and clinical teams. Methods: Cases of SARS-CoV-2 infection in children with CF aged less than 18 years were collated by the CF Registry Global Harmonization Group across 13 countries between 1 February and 7 August 2020. Results: Data on 105 children were collated and analysed. Median age of cases was ten years (interquartile range 6–15), 54% were male and median percentage predicted forced expiratory volume in one second was 94% (interquartile range 79–104). The majority (71%) of children were managed in the community during their COVID-19 illness. Out of 24 children admitted to hospital, six required supplementary oxygen and two non-invasive ventilation. Around half were prescribed antibiotics, five children received antiviral treatments, four azithromycin and one additional corticosteroids. Children that were hospitalised had lower lung function and reduced body mass index Z-scores. One child died six weeks after testing positive for SARS-CoV-2 following a deterioration that was not attributed to COVID-19 disease. Conclusions: SARS-CoV-2 infection in children with CF is usually associated with a mild illness in those who do not have pre-existing severe lung disease.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalJournal of Cystic Fibrosis
Volume20
Issue number1
DOIs
StatePublished - Jan 2021
Externally publishedYes

Keywords

  • COVID-19
  • Children
  • Cystic fibrosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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