Clinical characteristics of patients in a case control study of sarcoidosis

Robert P. Baughman, Alvin S. Teirstein, Marc A. Judson, Milton D. Rossman, Henry Yeager, Eddy A. Bresnitz, Louis DePalo, Gary Hunninghake, Michael C. Iannuzzi, Carol J. Johns, Geoffrey Mclennan, David R. Moller, Lee S. Newman, David L. Rabin, Cecile Rose, Benjamin Rybicki, Steven E. Weinberger, Michael L. Terrin, Genell L. Knatterud, Reuben Cherniak

Research output: Contribution to journalArticlepeer-review

Abstract

Sarcoidosis may be affected by sex, race, and age. A Case Control Etiologic Study of Sarcoidosis (ACCESS) enrolled 736 patients with sarcoidosis within 6 mo of diagnosis from 10 clinical centers in the United States. Using the ACCESS sarcoidosis assessment system, we determined organ involvement for the whole group and for subgroups differentiated by sex, race, and age (less than 40 yr or 40 yr and older). The study population was heterogeneous in terms of race (53% white, 44% black), sex (64% female, 36% male), and age (46% < 40 yr old, 54% ≥ 40 yr old). Women were more likely to have eye and neurologic involvement (x2 = 4.74, p < 0.05 and x2 = 4.60, p < 0.05 respectively), have erythema nodosum (x2 = 7.28, p < 0.01), and to be age 40 yr or over (x2 = 6.07, p < 0.02) whereas men were more likely to be hypercalcemic (x2 = 7.38, p < 0.01). Black subjects were more likely to have skin involvement other than erythema nodosum (x2 = 5.47, p < 0.05), and eye (x2 = 13.8, p < 0.0001), liver (x2 = 23.3, p < 0.0001), bone marrow (x2 = 18.8, p < 0.001), and extrathoracic lymph node involvement (x2 = 7.21, p < 0.01). We conclude that the initial presentation of sarcoidosis is related to sex, race, and age.

Original languageEnglish (US)
Pages (from-to)1885-1889
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Volume164
Issue number10 I
DOIs
StatePublished - Nov 15 2001
Externally publishedYes

Keywords

  • Age
  • Eye
  • Race
  • Sarcoidosis
  • Sex

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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