Clinical Characteristics and Treatment of 308 Panuveitis Patients over 10 Years: Results from the KKESH Uveitis Survey Study Group

The KKESH Uveitis Survey Study Group

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Abstract

Purpose: To describe the clinical characteristics and surgical outcomes of panuveitis over a 10-year period. Methods: Data were collected on panuveitis etiology, treatment, surgery and change in vision. Results: Overall, 308 patients (594 eyes) were evaluated, 54.9% with non-granulomatous and 45.1% with granulomatous uveitis. Fifty-four patients had infectious and 254 had non-infectious uveitis. In infectious panuveitis, vision remained unchanged at last visit. The most frequent diagnosis was presumed intraocular tuberculosis (PIOTB) uveitis (48.1%). In the non-infectious subgroup vision increased significantly by 2 lines at last visit (p = 0.020). The most common diagnose was Vogt–Koyanagi–Harada (VKH) disease (38.6%). Initial therapy was oral prednisone in 86.6% with non-infectious etiology followed by immunosuppressive agents. Surgery secondary to complications (mainly cataracts) was performed in 46.7% patients. Conclusion: In Saudi Arabia, panuveitis was mainly due to VHK. PIOTB was the most common etiology for infectious panuveitis. Immunosuppressive therapy and surgery maintained BCVA in non-infectious panuveitis.

Original languageEnglish (US)
JournalOcular Immunology and Inflammation
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Keywords

  • Panuveitis
  • presumed intraocular tuberculosis
  • uveitis
  • Vogt–Koyanagi–Harada (VKH) disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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