TY - JOUR
T1 - Clinical Characteristics and Treatment of 308 Panuveitis Patients over 10 Years
T2 - Results from the KKESH Uveitis Survey Study Group
AU - The KKESH Uveitis Survey Study Group
AU - Arevalo, J. Fernando
AU - Lasave, Andres F.
AU - Gupta, Vishali
AU - Kozak, Igor
AU - Al Shamsi, Hanan Nasser
AU - Al Suliman, Sulaiman Mohammad
AU - Al Rushood, Abdulaziz Adel
AU - Al-Zahrani, Yahya A.
AU - Al-Mahmood, Ammar M.
AU - Al Dhibi, Hassan A.
N1 - Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2019/11/17
Y1 - 2019/11/17
N2 - Purpose: To describe the clinical characteristics and surgical outcomes of panuveitis over a 10-year period. Methods: Data were collected on panuveitis etiology, treatment, surgery and change in vision. Results: Overall, 308 patients (594 eyes) were evaluated, 54.9% with non-granulomatous and 45.1% with granulomatous uveitis. Fifty-four patients had infectious and 254 had non-infectious uveitis. In infectious panuveitis, vision remained unchanged at last visit. The most frequent diagnosis was presumed intraocular tuberculosis (PIOTB) uveitis (48.1%). In the non-infectious subgroup vision increased significantly by 2 lines at last visit (p = 0.020). The most common diagnose was Vogt–Koyanagi–Harada (VKH) disease (38.6%). Initial therapy was oral prednisone in 86.6% with non-infectious etiology followed by immunosuppressive agents. Surgery secondary to complications (mainly cataracts) was performed in 46.7% patients. Conclusion: In Saudi Arabia, panuveitis was mainly due to VHK. PIOTB was the most common etiology for infectious panuveitis. Immunosuppressive therapy and surgery maintained BCVA in non-infectious panuveitis.
AB - Purpose: To describe the clinical characteristics and surgical outcomes of panuveitis over a 10-year period. Methods: Data were collected on panuveitis etiology, treatment, surgery and change in vision. Results: Overall, 308 patients (594 eyes) were evaluated, 54.9% with non-granulomatous and 45.1% with granulomatous uveitis. Fifty-four patients had infectious and 254 had non-infectious uveitis. In infectious panuveitis, vision remained unchanged at last visit. The most frequent diagnosis was presumed intraocular tuberculosis (PIOTB) uveitis (48.1%). In the non-infectious subgroup vision increased significantly by 2 lines at last visit (p = 0.020). The most common diagnose was Vogt–Koyanagi–Harada (VKH) disease (38.6%). Initial therapy was oral prednisone in 86.6% with non-infectious etiology followed by immunosuppressive agents. Surgery secondary to complications (mainly cataracts) was performed in 46.7% patients. Conclusion: In Saudi Arabia, panuveitis was mainly due to VHK. PIOTB was the most common etiology for infectious panuveitis. Immunosuppressive therapy and surgery maintained BCVA in non-infectious panuveitis.
KW - Panuveitis
KW - Vogt–Koyanagi–Harada (VKH) disease
KW - presumed intraocular tuberculosis
KW - uveitis
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U2 - 10.1080/09273948.2018.1523436
DO - 10.1080/09273948.2018.1523436
M3 - Article
C2 - 30303435
AN - SCOPUS:85054875502
SN - 0927-3948
VL - 27
SP - 1296
EP - 1304
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 8
ER -