Abstract
The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic 18FFDG scans to detect nodal disease. Methods: Patients undergoing routine 18F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal 18F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using 18F-FDG. Imaging of patients revealed the presence of 18F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of 18F-FDG is feasible and can aid in detecting disease in the clinical setting.
Original language | English (US) |
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Pages (from-to) | 95-98 |
Number of pages | 4 |
Journal | Journal of Nuclear Medicine |
Volume | 55 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2014 |
Externally published | Yes |
Keywords
- Cerenkov luminescence imaging
- Clinical
- PET/CT
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging