Clinical cerenkov luminescence imaging of 18F-FDG

Daniel L.J. Thorek; Christopher C. Riedl; Jan Grimm

doi:10.2967/jnumed.113.127266

Clinical cerenkov luminescence imaging of ¹⁸F-FDG

Daniel L.J. Thorek, Christopher C. Riedl, Jan Grimm

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic ¹⁸FFDG scans to detect nodal disease. Methods: Patients undergoing routine ¹⁸F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal ¹⁸F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using ¹⁸F-FDG. Imaging of patients revealed the presence of ¹⁸F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of ¹⁸F-FDG is feasible and can aid in detecting disease in the clinical setting.

Original language	English (US)
Pages (from-to)	95-98
Number of pages	4
Journal	Journal of Nuclear Medicine
Volume	55
Issue number	1
DOIs	https://doi.org/10.2967/jnumed.113.127266
State	Published - Jan 1 2014
Externally published	Yes

Keywords

Cerenkov luminescence imaging
Clinical
PET/CT

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.2967/jnumed.113.127266

Cite this

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title = "Clinical cerenkov luminescence imaging of 18F-FDG",

abstract = "The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic 18FFDG scans to detect nodal disease. Methods: Patients undergoing routine 18F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal 18F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using 18F-FDG. Imaging of patients revealed the presence of 18F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of 18F-FDG is feasible and can aid in detecting disease in the clinical setting.",

keywords = "Cerenkov luminescence imaging, Clinical, PET/CT",

author = "Thorek, {Daniel L.J.} and Riedl, {Christopher C.} and Jan Grimm",

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doi = "10.2967/jnumed.113.127266",

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AU - Thorek, Daniel L.J.

AU - Riedl, Christopher C.

AU - Grimm, Jan

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N2 - The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic 18FFDG scans to detect nodal disease. Methods: Patients undergoing routine 18F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal 18F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using 18F-FDG. Imaging of patients revealed the presence of 18F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of 18F-FDG is feasible and can aid in detecting disease in the clinical setting.

AB - The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic 18FFDG scans to detect nodal disease. Methods: Patients undergoing routine 18F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal 18F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using 18F-FDG. Imaging of patients revealed the presence of 18F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of 18F-FDG is feasible and can aid in detecting disease in the clinical setting.

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