Clinical case definitions for Argentine hemorrhagic fever

Lee H. Harrison, Neal A. Halsey, Kelly T. McKee, Clarence J. Peters, Julio G. Barrera Oro, Ana María Briggiler, María Rosa Feuillade, Julio I. Maiztegui

Research output: Contribution to journalArticlepeer-review

Abstract

Argentine hemorrhagic fever (AHF) is a potentially lethal infection in Argentina. The case-fatality ratio is > 15%, but treatment reduces the mortality rate to < 1%. Diagnosis is based on clinical and laboratory criteria, but no case definition has been validated. A chart review was conducted for patients hospitalized with suspected AHF. Individuals with a fourfold rise in antibody titer were classified as cases. The combination of a platelet count of <100,000/mm3 and a white blood cell (WBC) count of <2,500/mm3 had a sensitivity and specificity of 87% and 88%, respectively, thus suggesting that the use of these criteria in a case definition would be helpful for epidemiological studies of AHF. The combination of a platelet count of <100,000/mm3 and a WBC count of <4,000/mm3 had a sensitivity of 100% and a specificity of 71%; the use of these criteria in a case definition should be helpful for screening patients for therapy with immune plasma in the region where AHF is endemic.

Original languageEnglish (US)
Pages (from-to)1091-1094
Number of pages4
JournalClinical Infectious Diseases
Volume28
Issue number5
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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