Clinical case definitions for Argentine hemorrhagic fever

Lee H. Harrison, Neal A Halsey, Kelly T. McKee, Clarence J. Peters, Julio G. Barrera Oro, Ana María Briggiler, María Rosa Feuillade, Julio I. Maiztegui

Research output: Contribution to journalArticle

Abstract

Argentine hemorrhagic fever (AHF) is a potentially lethal infection in Argentina. The case-fatality ratio is > 15%, but treatment reduces the mortality rate to <1%. Diagnosis is based on clinical and laboratory criteria, but no case definition has been validated. A chart review was conducted for patients hospitalized with suspected AHF. Individuals with a fourfold rise in antibody titer were classified as cases. The combination of a platelet count of 3 and a white blood cell (WBC) count of 3 had a sensitivity and specificity of 87% and 88%, respectively, thus suggesting that the use of these criteria in a case definition would be helpful for epidemiological studies of AHF. The combination of a platelet count of 3 and a WBC count of 3 had a sensitivity of 100% and a specificity of 71%; the use of these criteria in a case definition should be helpful for screening patients for therapy with immune plasma in the region where AHF is endemic.

Original languageEnglish (US)
Pages (from-to)1091-1094
Number of pages4
JournalClinical Infectious Diseases
Volume28
Issue number5
StatePublished - 1999
Externally publishedYes

Fingerprint

Fever
Platelet Count
Leukocyte Count
Argentina
Epidemiologic Studies
Sensitivity and Specificity
Mortality
Antibodies
Therapeutics
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Harrison, L. H., Halsey, N. A., McKee, K. T., Peters, C. J., Barrera Oro, J. G., Briggiler, A. M., ... Maiztegui, J. I. (1999). Clinical case definitions for Argentine hemorrhagic fever. Clinical Infectious Diseases, 28(5), 1091-1094.

Clinical case definitions for Argentine hemorrhagic fever. / Harrison, Lee H.; Halsey, Neal A; McKee, Kelly T.; Peters, Clarence J.; Barrera Oro, Julio G.; Briggiler, Ana María; Feuillade, María Rosa; Maiztegui, Julio I.

In: Clinical Infectious Diseases, Vol. 28, No. 5, 1999, p. 1091-1094.

Research output: Contribution to journalArticle

Harrison, LH, Halsey, NA, McKee, KT, Peters, CJ, Barrera Oro, JG, Briggiler, AM, Feuillade, MR & Maiztegui, JI 1999, 'Clinical case definitions for Argentine hemorrhagic fever', Clinical Infectious Diseases, vol. 28, no. 5, pp. 1091-1094.
Harrison LH, Halsey NA, McKee KT, Peters CJ, Barrera Oro JG, Briggiler AM et al. Clinical case definitions for Argentine hemorrhagic fever. Clinical Infectious Diseases. 1999;28(5):1091-1094.
Harrison, Lee H. ; Halsey, Neal A ; McKee, Kelly T. ; Peters, Clarence J. ; Barrera Oro, Julio G. ; Briggiler, Ana María ; Feuillade, María Rosa ; Maiztegui, Julio I. / Clinical case definitions for Argentine hemorrhagic fever. In: Clinical Infectious Diseases. 1999 ; Vol. 28, No. 5. pp. 1091-1094.
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