TY - JOUR
T1 - Clinical Cancer Genetics Disparities among Latinos
AU - Cruz-Correa, Marcia
AU - Pérez-Mayoral, Julyann
AU - Dutil, Julie
AU - Echenique, Miguel
AU - Mosquera, Rafael
AU - Rivera-Román, Keila
AU - Umpierre, Sharee
AU - Rodriguez-Quilichini, Segundo
AU - Gonzalez-Pons, Maria
AU - Olivera, Myrta I.
AU - Pardo, Sherly
AU - On Behalf Of The Puerto Rico Clinical Cancer Genetics Consortia, Behalf Of The Puerto Rico Clinical Cancer Genetics Consortia
PY - 2016/12/12
Y1 - 2016/12/12
N2 - The three major hereditary cancer syndromes in Latinos (Hereditary Breast and Ovarian Cancer, Familial Adenomatous Polyposis and Lynch Syndrome) have been shown to exhibit geographic disparities by country of origin suggesting admixture-based disparities. A solid infrastructure of clinical genetics geared towards diagnosis and prevention could aid in reducing the mortality of these cancer syndromes in Latinos. Currently, clinical cancer genetic services in Latin America are scarce. Moreover, limited studies have investigated the mutational spectrum of these cancer syndromes in Latinos resulting in gaps in personalized medicine affecting diagnosis, treatment and prevention. The following commentary discusses available genotype and clinical information on hereditary cancer in Latinos and highlights the limited access for cancer genetic services in Latin America including barriers to genetic testing and alternatives for providing better access to genetic services. In this review, we discuss the status of clinical genetic cancer services for both US Latinos and those Latinos living in Latin America.
AB - The three major hereditary cancer syndromes in Latinos (Hereditary Breast and Ovarian Cancer, Familial Adenomatous Polyposis and Lynch Syndrome) have been shown to exhibit geographic disparities by country of origin suggesting admixture-based disparities. A solid infrastructure of clinical genetics geared towards diagnosis and prevention could aid in reducing the mortality of these cancer syndromes in Latinos. Currently, clinical cancer genetic services in Latin America are scarce. Moreover, limited studies have investigated the mutational spectrum of these cancer syndromes in Latinos resulting in gaps in personalized medicine affecting diagnosis, treatment and prevention. The following commentary discusses available genotype and clinical information on hereditary cancer in Latinos and highlights the limited access for cancer genetic services in Latin America including barriers to genetic testing and alternatives for providing better access to genetic services. In this review, we discuss the status of clinical genetic cancer services for both US Latinos and those Latinos living in Latin America.
KW - Genetic counseling
KW - Genetic testing
KW - Health disparities
KW - Hereditary cancer
KW - Hispanics
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U2 - 10.1007/s10897-016-0051-x
DO - 10.1007/s10897-016-0051-x
M3 - Article
AN - SCOPUS:85004024119
SN - 1059-7700
SP - 1
EP - 8
JO - Journal of Genetic Counseling
JF - Journal of Genetic Counseling
ER -