Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA

Bo Deng, Julian Molina, Marie C. Aubry, Zhifu Sun, Liang Wang, Bruce W. Eckloff, George Vasmatzis, Ming You, Eric D. Wieben, Jin Jen, Dennis A. Wigle, Ping Yang

Research output: Contribution to journalArticle

Abstract

Background: miRNAs play key regulatory roles in cellular pathological processes. We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profiling miRNAs and mRNAs.Results: From the total of 1145 miRNAs, we obtained 16 and 17 miRNAs that showed positive and negative fold changes (FCs, tumors vs. normal tissues) in the top 1% differentially expressed miRNAs, respectively. We uncovered the target genes that were predicted by at least two prediction tools and overlapped by at least one-half of the top miRNAs, which yielded 44 genes (FC<-2) and 56 genes (FC>2), respectively. Higher expressions of CREB5, PTPRB and COL4A3 predicted favorable disease free survival (Hazard ratio: 0.03, 0.19 and 0.36; P value: 0.03, 0.03 and 0.08). Additionally, 79 mutated genes have been found in nine PCTs where TP53 was the only repeated mutation.Conclusion: We identified that the expressions of three genes have clinical implications in PCTs. The biological functions of these biomarkers warrant further studies.

Original languageEnglish (US)
Article number35
JournalCell and Bioscience
Volume4
Issue number1
DOIs
StatePublished - Jul 9 2014
Externally publishedYes

Keywords

  • Carcinoid
  • miRNA
  • mRNA
  • Survival

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Deng, B., Molina, J., Aubry, M. C., Sun, Z., Wang, L., Eckloff, B. W., Vasmatzis, G., You, M., Wieben, E. D., Jen, J., Wigle, D. A., & Yang, P. (2014). Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. Cell and Bioscience, 4(1), [35]. https://doi.org/10.1186/2045-3701-4-35