Clinical assessment of left ventricular rotation and strain: A novel approach for quantification of function in infarcted myocardium and its border zones

Thomas Helle-Valle, Espen W. Remme, Erik Lyseggen, Eirik Pettersen, Trond Vartdal, Anders Opdahl, Hans Jørgen Smith, Nael Fakhry Osman, Halfdan Ihlen, Thor Edvardsen, Otto A. Smiseth

Research output: Contribution to journalArticle

Abstract

Left ventricular (LV) circumferential strain and rotation have been introduced as clinical markers of myocardial function. This study investigates how regional LV apical rotation and strain can be used in combination to assess function in the infarcted ventricle. In healthy subjects (n = 15) and patients with myocardial infarction (n = 23), LV apical segmental rotation and strain were measured from apical short-axis recordings by speckle tracking echocardiography (STE) and MRI tagging. Infarct extent was determined by late gadolinium enhancement MRI. To investigate mechanisms of changes in strain and rotation, we used a mathematical finite element simulation model of the LV. Mean apical rotation and strain by STE were lower in patients than in healthy subjects (9.0 ± 4.9 vs. 12.9 ± 3.5° and -13.9 ± 10.7 vs. -23.8 ± 2.3%, respectively, P <0.05). In patients, regional strain was reduced in proportion to segmental infarct extent (r = 0.80, P <0.0001). Regional rotation, however, was similar in the center of the infarct and in remote viable myocardium. Minimum and maximum rotations were found at the infarct borders: minimum rotation at the border zone opposite to the direction of apical rotation, and maximum rotation at the border zone in the direction of rotation. The simulation model reproduced the clinical findings and indicated that the dissociation between rotation and strain was caused by mechanical interactions between infarcted and viable myocardium. Systolic strain reflects regional myocardial function and infarct extent, whereas systolic rotation defines infarct borders in the LV apical region. Regional rotation, however, has limited ability to quantify regional myocardial dysfunction.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume297
Issue number1
DOIs
StatePublished - Jul 2009

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Myocardium
Echocardiography
Healthy Volunteers
Myocardial Infarction
Gadolinium
Biomarkers

Keywords

  • Left ventricular function
  • Left ventricular torsion
  • Myocardial infarction
  • Myocardial strain

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Clinical assessment of left ventricular rotation and strain : A novel approach for quantification of function in infarcted myocardium and its border zones. / Helle-Valle, Thomas; Remme, Espen W.; Lyseggen, Erik; Pettersen, Eirik; Vartdal, Trond; Opdahl, Anders; Smith, Hans Jørgen; Osman, Nael Fakhry; Ihlen, Halfdan; Edvardsen, Thor; Smiseth, Otto A.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 297, No. 1, 07.2009.

Research output: Contribution to journalArticle

Helle-Valle, Thomas ; Remme, Espen W. ; Lyseggen, Erik ; Pettersen, Eirik ; Vartdal, Trond ; Opdahl, Anders ; Smith, Hans Jørgen ; Osman, Nael Fakhry ; Ihlen, Halfdan ; Edvardsen, Thor ; Smiseth, Otto A. / Clinical assessment of left ventricular rotation and strain : A novel approach for quantification of function in infarcted myocardium and its border zones. In: American Journal of Physiology - Heart and Circulatory Physiology. 2009 ; Vol. 297, No. 1.
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AU - Vartdal, Trond

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AU - Smith, Hans Jørgen

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AB - Left ventricular (LV) circumferential strain and rotation have been introduced as clinical markers of myocardial function. This study investigates how regional LV apical rotation and strain can be used in combination to assess function in the infarcted ventricle. In healthy subjects (n = 15) and patients with myocardial infarction (n = 23), LV apical segmental rotation and strain were measured from apical short-axis recordings by speckle tracking echocardiography (STE) and MRI tagging. Infarct extent was determined by late gadolinium enhancement MRI. To investigate mechanisms of changes in strain and rotation, we used a mathematical finite element simulation model of the LV. Mean apical rotation and strain by STE were lower in patients than in healthy subjects (9.0 ± 4.9 vs. 12.9 ± 3.5° and -13.9 ± 10.7 vs. -23.8 ± 2.3%, respectively, P <0.05). In patients, regional strain was reduced in proportion to segmental infarct extent (r = 0.80, P <0.0001). Regional rotation, however, was similar in the center of the infarct and in remote viable myocardium. Minimum and maximum rotations were found at the infarct borders: minimum rotation at the border zone opposite to the direction of apical rotation, and maximum rotation at the border zone in the direction of rotation. The simulation model reproduced the clinical findings and indicated that the dissociation between rotation and strain was caused by mechanical interactions between infarcted and viable myocardium. Systolic strain reflects regional myocardial function and infarct extent, whereas systolic rotation defines infarct borders in the LV apical region. Regional rotation, however, has limited ability to quantify regional myocardial dysfunction.

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