Clinical aspects of medullary thyroid carcinoma

Research output: Chapter in Book/Report/Conference proceedingChapter


Medullary thyroid cancer (MTC), an uncommon neoplasm stemming from the calcitonin-producing thyroid parafollicular C cells, represents approximately 5% of thyroid cancer cases. Unique among all types of thyroid cancer is the close association of MTC with inherited tumor syndromes in about 20% of patients. Activating mutations in the ret proto-oncogene account for the hereditary basis of MTC and contribute significantly to sporadic tumor development as well. These findings have a major impact on the diagnosis and therapy of MTC.

Original languageEnglish (US)
Title of host publicationThyroid Cancer (Second Edition)
Subtitle of host publicationA Comprehensive Guide to Clinical Management
PublisherHumana Press
Number of pages9
ISBN (Print)9781588294623
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Medicine(all)


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