Medullary thyroid cancer (MTC), an uncommon neoplasm stemming from the calcitonin-producing thyroid parafollicular C cells, represents approximately 5% of thyroid cancer cases. Unique among all types of thyroid cancer is the close association of MTC with inherited tumor syndromes in about 20% of patients. Activating mutations in the ret proto-oncogene account for the hereditary basis of MTC and contribute significantly to sporadic tumor development as well. These findings have a major impact on the diagnosis and therapy of MTC.
|Original language||English (US)|
|Title of host publication||Thyroid Cancer (Second Edition)|
|Subtitle of host publication||A Comprehensive Guide to Clinical Management|
|Number of pages||9|
|State||Published - Dec 1 2006|
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