Clinical aspects of medullary thyroid carcinoma

Douglas W. Ball

doi:10.1007/978-1-59259-995-0_70

Clinical aspects of medullary thyroid carcinoma

Douglas W. Ball

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Medullary thyroid cancer (MTC), an uncommon neoplasm stemming from the calcitonin-producing thyroid parafollicular C cells, represents approximately 5% of thyroid cancer cases. Unique among all types of thyroid cancer is the close association of MTC with inherited tumor syndromes in about 20% of patients. Activating mutations in the ret proto-oncogene account for the hereditary basis of MTC and contribute significantly to sporadic tumor development as well. These findings have a major impact on the diagnosis and therapy of MTC.

Original language	English (US)
Title of host publication	Thyroid Cancer (Second Edition)
Subtitle of host publication	A Comprehensive Guide to Clinical Management
Publisher	Humana Press
Pages	581-589
Number of pages	9
ISBN (Print)	9781588294623
DOIs	https://doi.org/10.1007/978-1-59259-995-0_70
State	Published - Dec 1 2006

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-59259-995-0_70

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abstract = "Medullary thyroid cancer (MTC), an uncommon neoplasm stemming from the calcitonin-producing thyroid parafollicular C cells, represents approximately 5% of thyroid cancer cases. Unique among all types of thyroid cancer is the close association of MTC with inherited tumor syndromes in about 20% of patients. Activating mutations in the ret proto-oncogene account for the hereditary basis of MTC and contribute significantly to sporadic tumor development as well. These findings have a major impact on the diagnosis and therapy of MTC.",

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AB - Medullary thyroid cancer (MTC), an uncommon neoplasm stemming from the calcitonin-producing thyroid parafollicular C cells, represents approximately 5% of thyroid cancer cases. Unique among all types of thyroid cancer is the close association of MTC with inherited tumor syndromes in about 20% of patients. Activating mutations in the ret proto-oncogene account for the hereditary basis of MTC and contribute significantly to sporadic tumor development as well. These findings have a major impact on the diagnosis and therapy of MTC.

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Clinical aspects of medullary thyroid carcinoma

Abstract

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