Clinical aspects of cell death in breast cancer: The polyamine pathway as a new target for treatment

N. E. Davidson, H. A. Hahm, D. E. McCloskey, P. M. Woster, R. A. Casero

Research output: Contribution to journalArticle

Abstract

Because intracellular polyamines have a critical role in cell proliferation and death pathways, the polyamine metabolic pathway represents a potential target for intervention in cancers. A number of polyamine analogues have been identified that downregulate polyamine synthesis and enhance polyamine catabolism, thereby depleting intracellular polyamines. Treatment of human breast cancer cell lines in culture with these analogues has been shown to decrease cell proliferation and induce programmed cell death. Phase I studies with one analogue are now complete, setting the stage for phase II trials to determine efficacy, in addition to preclinical studies to examine combinations of polyamine analogues and conventional cytotoxics.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalEndocrine-related cancer
Volume6
Issue number1
DOIs
StatePublished - Mar 1 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

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