Clinical applications of genomics in head and neck cancer

Christine H. Chung, Shawn Levy, Wendell G. Yarbrough

Research output: Contribution to journalArticlepeer-review

Abstract

Advances in gene expression analyses have allowed global assessment of expressed genes in clinical samples. Gene expression profiles derived from clinical specimens have been used to distinguish differences in tumors that are not obvious by clinical, radiographic, or histologic characteristics. Despite its common histology and presentation, head and neck squamous cell carcinoma (HNSCC) is associated with widely varying clinical behavior and response to therapy. Currently, clinicians have a dearth of tools to predict response to therapy or to identify patients at high risk of poor outcome. Recently comprehensive analyses of gene expression patterns of individual tumors have shown promise to improve discovery of biomarkers for 1) progression of premalignant lesions, 2) disease presence or absence, 3) prediction of clinical outcome, and 4) identification of targets for therapy. In this review, we will discuss advances limitations and future directions of genomics as it applies to HNSCC.

Original languageEnglish (US)
Pages (from-to)360-368
Number of pages9
JournalHead and Neck
Volume28
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Keywords

  • Biomarkers
  • DNA microarray
  • Genomics
  • Head and heck cancer
  • Predictive profiles

ASJC Scopus subject areas

  • Otorhinolaryngology

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