Clinical and radiologic disease in smokers with normal spirometry

Elizabeth A. Regan, David A. Lynch, Douglas Curran-Everett, Jeffrey L. Curtis, John H.M. Austin, Philippe A. Grenier, Hans Ulrich Kauczor, William C. Bailey, Dawn L. De Meo, Richard H. Casaburi, Paul Friedman, Edwin J.R. Van Beek, John E. Hokanson, Russell P. Bowler, Terri H. Beaty, George R. Washko, Meilan K. Han, Victor Kim, Song Soo Kim, Kunihiro YagihashiLacey Washington, Charlene E. McEvoy, Clint Tanner, David M. Mannino, Barry J. Make, Edwin K. Silverman, James D. Crapo, Carlos Martinez, Perry G. Pernicano, Nicola Hanania, Philip Alapat, Venkata Bandi, Mustafa Atik, Aladin Boriek, Kalpatha Guntupalli, Elizabeth Guy, Amit Parulekar, Arun Nachiappan, Craig Hersh, Francine Jacobson, R. Graham Barr, Byron Thomashow, Belinda D'Souza, Gregory D.N. Pearson, Anna Rozenshtein, Neil MacIntyre, H. Page McAdams, Joseph Tashjian, Robert Wise, Nadia Hansel, Robert Brown, Karen Horton, Nirupama Putcha, Alessandra Adami, Janos Porszasz, Hans Fischer, Matthew Budoff, Dan Cannon, Harry Rossiter, Amir Sharafkhaneh, Charlie Lan, Christine Wendt, Brian Bell, Marilyn Foreman, Gloria Westney, Eugene Berkowitz, Richard Rosiello, David Pace, Gerard Criner, David Ciccolella, Francis Cordova, Chandra Dass, Robert D'Alonzo, Parag Desai, Michael Jacobs, Steven Kelsen, A. James Mamary, Nathaniel Marchetti, Aditti Satti, Kartik Shenoy, Robert M. Steiner, Alex Swift, Irene Swift, Gloria Vega-Sanchez, Mark Dransfield, J. Michael Wells, Surya Bhatt, Hrudaya Nath, Joe Ramsdell, Xavier Soler, Andrew Yen, Alejandro Cornellas, John Newell, Brad Thompson, Ella Kazerooni, Fernando Martinez, Joanne Billings, Tadashi Allen, Frank Sciurba, Divay Chandra, Joel Weissfeld, Carl Fuhrman, Jessica Bon, Antonio Anzueto, Sandra Adams, Diego Maselli-Caceres, Mario E. Ruiz

Research output: Contribution to journalArticle

Abstract

IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free. OBJECTIVE: To identify clinical and radiologic evidence of smoking-related disease in a cohort of current and former smokers who did not meet spirometric criteria for COPD, for whom we adopted the discarded label of Global Initiative for Obstructive Lung Disease (GOLD) 0. DESIGN, SETTING, AND PARTICIPANTS: Individuals from the Genetic Epidemiology of COPD (COPDGene) cross-sectional observational study completed spirometry, chest computed tomography (CT) scans, a 6-minute walk, and questionnaires. Participants were recruited from local communities at 21 sites across the United States. The GOLD 0 group (n = 4388) (ratio of forced expiratory volume in the first second of expiration [FEV1] to forced vital capacity >0.7 and FEV1 >80% predicted) from the COPDGene study was compared with a GOLD 1 group (n = 794), COPD groups (n = 3690), and a group of never smokers (n = 108). Recruitment began in January 2008 and ended in July 2011. MAIN OUTCOMES AND MEASURES: Physical function impairments, respiratory symptoms, CT abnormalities, use of respiratory medications, and reduced respiratory-specific quality of life. RESULTS: One or more respiratory-related impairments were found in 54.1% (2375 of 4388) of the GOLD 0 group. The GOLD 0 group had worse quality of life (mean [SD] St George's Respiratory Questionnaire total score, 17.0 [18.0] vs 3.8 [6.8] for the never smokers; P <001) and a lower 6-minute walk distance, and 42.3% (127 of 300) of the GOLD 0 group had CT evidence of emphysema or airway thickening. The FEV1 percent predicted distribution and mean for the GOLD 0 group were lower but still within the normal range for the population. Current smoking was associated with more respiratory symptoms, but former smokers had greater emphysema and gas trapping. Advancing age was associated with smoking cessation and with more CT findings of disease. Individuals with respiratory impairments were more likely to use respiratory medications, and the use of these medications was associated with worse disease. CONCLUSIONS AND RELEVANCE: Lung disease and impairments were common in smokers without spirometric COPD. Based on these results, we project that there are 35 million current and former smokers older than 55 years in the United States who may have unrecognized disease or impairment. The effect of chronic smoking on the lungs and the individual is substantially underestimated when using spirometry alone.

Original languageEnglish (US)
Pages (from-to)1539-1549
Number of pages11
JournalJAMA internal medicine
Volume175
Issue number9
DOIs
StatePublished - Sep 1 2015

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ASJC Scopus subject areas

  • Internal Medicine

Cite this

Regan, E. A., Lynch, D. A., Curran-Everett, D., Curtis, J. L., Austin, J. H. M., Grenier, P. A., Kauczor, H. U., Bailey, W. C., De Meo, D. L., Casaburi, R. H., Friedman, P., Van Beek, E. J. R., Hokanson, J. E., Bowler, R. P., Beaty, T. H., Washko, G. R., Han, M. K., Kim, V., Kim, S. S., ... Ruiz, M. E. (2015). Clinical and radiologic disease in smokers with normal spirometry. JAMA internal medicine, 175(9), 1539-1549. https://doi.org/10.1001/jamainternmed.2015.2735