Clinical and radiologic disease in smokers with normal spirometry

Elizabeth A. Regan, David A. Lynch, Douglas Curran-Everett, Jeffrey L. Curtis, John H M Austin, Philippe A. Grenier, Hans Ulrich Kauczor, William C. Bailey, Dawn L. De Meo, Richard H. Casaburi, Paul Friedman, Edwin J R Van Beek, John E. Hokanson, Russell P. Bowler, Terri L Beaty, George R. Washko, Meilan K. Han, Victor Kim, Song Soo Kim, Kunihiro Yagihashi & 87 others Lacey Washington, Charlene E. McEvoy, Clint Tanner, David M. Mannino, Barry J. Make, Edwin K. Silverman, James D. Crapo, Carlos Martinez, Perry G. Pernicano, Nicola Hanania, Philip Alapat, Venkata Bandi, Mustafa Atik, Aladin Boriek, Kalpatha Guntupalli, Elizabeth Guy, Amit Parulekar, Arun Nachiappan, Craig Hersh, Francine Jacobson, R. Graham Barr, Byron Thomashow, Belinda D'Souza, Gregory D N Pearson, Anna Rozenshtein, Neil MacIntyre, H. Page McAdams, Joseph Tashjian, Robert A Wise, Nadia Hansel, Robert Howard Brown, Karen M Horton, Nirupama Putcha, Alessandra Adami, Janos Porszasz, Hans Fischer, Matthew Budoff, Dan Cannon, Harry Rossiter, Amir Sharafkhaneh, Charlie Lan, Christine Wendt, Brian Bell, Marilyn Foreman, Gloria Westney, Eugene Berkowitz, Richard Rosiello, David Pace, Gerard Criner, David Ciccolella, Francis Cordova, Chandra Dass, Robert D'Alonzo, Parag Desai, Michael Jacobs, Steven Kelsen, A. James Mamary, Nathaniel Marchetti, Aditti Satti, Kartik Shenoy, Robert M. Steiner, Alex Swift, Irene Swift, Gloria Vega-Sanchez, Mark Dransfield, J. Michael Wells, Surya Bhatt, Hrudaya Nath, Joe Ramsdell, Xavier Soler, Andrew Yen, Alejandro Cornellas, John Newell, Brad Thompson, Ella Kazerooni, Fernando Martinez, Joanne Billings, Tadashi Allen, Frank Sciurba, Divay Chandra, Joel Weissfeld, Carl Fuhrman, Jessica Bon, Antonio Anzueto, Sandra Adams, Diego Maselli-Caceres, Mario E. Ruiz

Research output: Contribution to journalArticle

Abstract

IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free. OBJECTIVE: To identify clinical and radiologic evidence of smoking-related disease in a cohort of current and former smokers who did not meet spirometric criteria for COPD, for whom we adopted the discarded label of Global Initiative for Obstructive Lung Disease (GOLD) 0. DESIGN, SETTING, AND PARTICIPANTS: Individuals from the Genetic Epidemiology of COPD (COPDGene) cross-sectional observational study completed spirometry, chest computed tomography (CT) scans, a 6-minute walk, and questionnaires. Participants were recruited from local communities at 21 sites across the United States. The GOLD 0 group (n = 4388) (ratio of forced expiratory volume in the first second of expiration [FEV1] to forced vital capacity >0.7 and FEV1 >80% predicted) from the COPDGene study was compared with a GOLD 1 group (n = 794), COPD groups (n = 3690), and a group of never smokers (n = 108). Recruitment began in January 2008 and ended in July 2011. MAIN OUTCOMES AND MEASURES: Physical function impairments, respiratory symptoms, CT abnormalities, use of respiratory medications, and reduced respiratory-specific quality of life. RESULTS: One or more respiratory-related impairments were found in 54.1% (2375 of 4388) of the GOLD 0 group. The GOLD 0 group had worse quality of life (mean [SD] St George's Respiratory Questionnaire total score, 17.0 [18.0] vs 3.8 [6.8] for the never smokers; P

Original languageEnglish (US)
Pages (from-to)1539-1549
Number of pages11
JournalJAMA Internal Medicine
Volume175
Issue number9
DOIs
StatePublished - Sep 1 2015

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Obstructive Lung Diseases
Spirometry
Chronic Obstructive Pulmonary Disease
Tomography
Quality of Life
Molecular Epidemiology
Vital Capacity
Forced Expiratory Volume
Observational Studies
Thorax
Cross-Sectional Studies
Smoking
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Regan, E. A., Lynch, D. A., Curran-Everett, D., Curtis, J. L., Austin, J. H. M., Grenier, P. A., ... Ruiz, M. E. (2015). Clinical and radiologic disease in smokers with normal spirometry. JAMA Internal Medicine, 175(9), 1539-1549. https://doi.org/10.1001/jamainternmed.2015.2735

Clinical and radiologic disease in smokers with normal spirometry. / Regan, Elizabeth A.; Lynch, David A.; Curran-Everett, Douglas; Curtis, Jeffrey L.; Austin, John H M; Grenier, Philippe A.; Kauczor, Hans Ulrich; Bailey, William C.; De Meo, Dawn L.; Casaburi, Richard H.; Friedman, Paul; Van Beek, Edwin J R; Hokanson, John E.; Bowler, Russell P.; Beaty, Terri L; Washko, George R.; Han, Meilan K.; Kim, Victor; Kim, Song Soo; Yagihashi, Kunihiro; Washington, Lacey; McEvoy, Charlene E.; Tanner, Clint; Mannino, David M.; Make, Barry J.; Silverman, Edwin K.; Crapo, James D.; Martinez, Carlos; Pernicano, Perry G.; Hanania, Nicola; Alapat, Philip; Bandi, Venkata; Atik, Mustafa; Boriek, Aladin; Guntupalli, Kalpatha; Guy, Elizabeth; Parulekar, Amit; Nachiappan, Arun; Hersh, Craig; Jacobson, Francine; Barr, R. Graham; Thomashow, Byron; D'Souza, Belinda; Pearson, Gregory D N; Rozenshtein, Anna; MacIntyre, Neil; McAdams, H. Page; Tashjian, Joseph; Wise, Robert A; Hansel, Nadia; Brown, Robert Howard; Horton, Karen M; Putcha, Nirupama; Adami, Alessandra; Porszasz, Janos; Fischer, Hans; Budoff, Matthew; Cannon, Dan; Rossiter, Harry; Sharafkhaneh, Amir; Lan, Charlie; Wendt, Christine; Bell, Brian; Foreman, Marilyn; Westney, Gloria; Berkowitz, Eugene; Rosiello, Richard; Pace, David; Criner, Gerard; Ciccolella, David; Cordova, Francis; Dass, Chandra; D'Alonzo, Robert; Desai, Parag; Jacobs, Michael; Kelsen, Steven; Mamary, A. James; Marchetti, Nathaniel; Satti, Aditti; Shenoy, Kartik; Steiner, Robert M.; Swift, Alex; Swift, Irene; Vega-Sanchez, Gloria; Dransfield, Mark; Wells, J. Michael; Bhatt, Surya; Nath, Hrudaya; Ramsdell, Joe; Soler, Xavier; Yen, Andrew; Cornellas, Alejandro; Newell, John; Thompson, Brad; Kazerooni, Ella; Martinez, Fernando; Billings, Joanne; Allen, Tadashi; Sciurba, Frank; Chandra, Divay; Weissfeld, Joel; Fuhrman, Carl; Bon, Jessica; Anzueto, Antonio; Adams, Sandra; Maselli-Caceres, Diego; Ruiz, Mario E.

In: JAMA Internal Medicine, Vol. 175, No. 9, 01.09.2015, p. 1539-1549.

Research output: Contribution to journalArticle

Regan, EA, Lynch, DA, Curran-Everett, D, Curtis, JL, Austin, JHM, Grenier, PA, Kauczor, HU, Bailey, WC, De Meo, DL, Casaburi, RH, Friedman, P, Van Beek, EJR, Hokanson, JE, Bowler, RP, Beaty, TL, Washko, GR, Han, MK, Kim, V, Kim, SS, Yagihashi, K, Washington, L, McEvoy, CE, Tanner, C, Mannino, DM, Make, BJ, Silverman, EK, Crapo, JD, Martinez, C, Pernicano, PG, Hanania, N, Alapat, P, Bandi, V, Atik, M, Boriek, A, Guntupalli, K, Guy, E, Parulekar, A, Nachiappan, A, Hersh, C, Jacobson, F, Barr, RG, Thomashow, B, D'Souza, B, Pearson, GDN, Rozenshtein, A, MacIntyre, N, McAdams, HP, Tashjian, J, Wise, RA, Hansel, N, Brown, RH, Horton, KM, Putcha, N, Adami, A, Porszasz, J, Fischer, H, Budoff, M, Cannon, D, Rossiter, H, Sharafkhaneh, A, Lan, C, Wendt, C, Bell, B, Foreman, M, Westney, G, Berkowitz, E, Rosiello, R, Pace, D, Criner, G, Ciccolella, D, Cordova, F, Dass, C, D'Alonzo, R, Desai, P, Jacobs, M, Kelsen, S, Mamary, AJ, Marchetti, N, Satti, A, Shenoy, K, Steiner, RM, Swift, A, Swift, I, Vega-Sanchez, G, Dransfield, M, Wells, JM, Bhatt, S, Nath, H, Ramsdell, J, Soler, X, Yen, A, Cornellas, A, Newell, J, Thompson, B, Kazerooni, E, Martinez, F, Billings, J, Allen, T, Sciurba, F, Chandra, D, Weissfeld, J, Fuhrman, C, Bon, J, Anzueto, A, Adams, S, Maselli-Caceres, D & Ruiz, ME 2015, 'Clinical and radiologic disease in smokers with normal spirometry', JAMA Internal Medicine, vol. 175, no. 9, pp. 1539-1549. https://doi.org/10.1001/jamainternmed.2015.2735
Regan EA, Lynch DA, Curran-Everett D, Curtis JL, Austin JHM, Grenier PA et al. Clinical and radiologic disease in smokers with normal spirometry. JAMA Internal Medicine. 2015 Sep 1;175(9):1539-1549. https://doi.org/10.1001/jamainternmed.2015.2735
Regan, Elizabeth A. ; Lynch, David A. ; Curran-Everett, Douglas ; Curtis, Jeffrey L. ; Austin, John H M ; Grenier, Philippe A. ; Kauczor, Hans Ulrich ; Bailey, William C. ; De Meo, Dawn L. ; Casaburi, Richard H. ; Friedman, Paul ; Van Beek, Edwin J R ; Hokanson, John E. ; Bowler, Russell P. ; Beaty, Terri L ; Washko, George R. ; Han, Meilan K. ; Kim, Victor ; Kim, Song Soo ; Yagihashi, Kunihiro ; Washington, Lacey ; McEvoy, Charlene E. ; Tanner, Clint ; Mannino, David M. ; Make, Barry J. ; Silverman, Edwin K. ; Crapo, James D. ; Martinez, Carlos ; Pernicano, Perry G. ; Hanania, Nicola ; Alapat, Philip ; Bandi, Venkata ; Atik, Mustafa ; Boriek, Aladin ; Guntupalli, Kalpatha ; Guy, Elizabeth ; Parulekar, Amit ; Nachiappan, Arun ; Hersh, Craig ; Jacobson, Francine ; Barr, R. Graham ; Thomashow, Byron ; D'Souza, Belinda ; Pearson, Gregory D N ; Rozenshtein, Anna ; MacIntyre, Neil ; McAdams, H. Page ; Tashjian, Joseph ; Wise, Robert A ; Hansel, Nadia ; Brown, Robert Howard ; Horton, Karen M ; Putcha, Nirupama ; Adami, Alessandra ; Porszasz, Janos ; Fischer, Hans ; Budoff, Matthew ; Cannon, Dan ; Rossiter, Harry ; Sharafkhaneh, Amir ; Lan, Charlie ; Wendt, Christine ; Bell, Brian ; Foreman, Marilyn ; Westney, Gloria ; Berkowitz, Eugene ; Rosiello, Richard ; Pace, David ; Criner, Gerard ; Ciccolella, David ; Cordova, Francis ; Dass, Chandra ; D'Alonzo, Robert ; Desai, Parag ; Jacobs, Michael ; Kelsen, Steven ; Mamary, A. James ; Marchetti, Nathaniel ; Satti, Aditti ; Shenoy, Kartik ; Steiner, Robert M. ; Swift, Alex ; Swift, Irene ; Vega-Sanchez, Gloria ; Dransfield, Mark ; Wells, J. Michael ; Bhatt, Surya ; Nath, Hrudaya ; Ramsdell, Joe ; Soler, Xavier ; Yen, Andrew ; Cornellas, Alejandro ; Newell, John ; Thompson, Brad ; Kazerooni, Ella ; Martinez, Fernando ; Billings, Joanne ; Allen, Tadashi ; Sciurba, Frank ; Chandra, Divay ; Weissfeld, Joel ; Fuhrman, Carl ; Bon, Jessica ; Anzueto, Antonio ; Adams, Sandra ; Maselli-Caceres, Diego ; Ruiz, Mario E. / Clinical and radiologic disease in smokers with normal spirometry. In: JAMA Internal Medicine. 2015 ; Vol. 175, No. 9. pp. 1539-1549.
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abstract = "IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free. OBJECTIVE: To identify clinical and radiologic evidence of smoking-related disease in a cohort of current and former smokers who did not meet spirometric criteria for COPD, for whom we adopted the discarded label of Global Initiative for Obstructive Lung Disease (GOLD) 0. DESIGN, SETTING, AND PARTICIPANTS: Individuals from the Genetic Epidemiology of COPD (COPDGene) cross-sectional observational study completed spirometry, chest computed tomography (CT) scans, a 6-minute walk, and questionnaires. Participants were recruited from local communities at 21 sites across the United States. The GOLD 0 group (n = 4388) (ratio of forced expiratory volume in the first second of expiration [FEV1] to forced vital capacity >0.7 and FEV1 >80{\%} predicted) from the COPDGene study was compared with a GOLD 1 group (n = 794), COPD groups (n = 3690), and a group of never smokers (n = 108). Recruitment began in January 2008 and ended in July 2011. MAIN OUTCOMES AND MEASURES: Physical function impairments, respiratory symptoms, CT abnormalities, use of respiratory medications, and reduced respiratory-specific quality of life. RESULTS: One or more respiratory-related impairments were found in 54.1{\%} (2375 of 4388) of the GOLD 0 group. The GOLD 0 group had worse quality of life (mean [SD] St George's Respiratory Questionnaire total score, 17.0 [18.0] vs 3.8 [6.8] for the never smokers; P",
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T1 - Clinical and radiologic disease in smokers with normal spirometry

AU - Regan, Elizabeth A.

AU - Lynch, David A.

AU - Curran-Everett, Douglas

AU - Curtis, Jeffrey L.

AU - Austin, John H M

AU - Grenier, Philippe A.

AU - Kauczor, Hans Ulrich

AU - Bailey, William C.

AU - De Meo, Dawn L.

AU - Casaburi, Richard H.

AU - Friedman, Paul

AU - Van Beek, Edwin J R

AU - Hokanson, John E.

AU - Bowler, Russell P.

AU - Beaty, Terri L

AU - Washko, George R.

AU - Han, Meilan K.

AU - Kim, Victor

AU - Kim, Song Soo

AU - Yagihashi, Kunihiro

AU - Washington, Lacey

AU - McEvoy, Charlene E.

AU - Tanner, Clint

AU - Mannino, David M.

AU - Make, Barry J.

AU - Silverman, Edwin K.

AU - Crapo, James D.

AU - Martinez, Carlos

AU - Pernicano, Perry G.

AU - Hanania, Nicola

AU - Alapat, Philip

AU - Bandi, Venkata

AU - Atik, Mustafa

AU - Boriek, Aladin

AU - Guntupalli, Kalpatha

AU - Guy, Elizabeth

AU - Parulekar, Amit

AU - Nachiappan, Arun

AU - Hersh, Craig

AU - Jacobson, Francine

AU - Barr, R. Graham

AU - Thomashow, Byron

AU - D'Souza, Belinda

AU - Pearson, Gregory D N

AU - Rozenshtein, Anna

AU - MacIntyre, Neil

AU - McAdams, H. Page

AU - Tashjian, Joseph

AU - Wise, Robert A

AU - Hansel, Nadia

AU - Brown, Robert Howard

AU - Horton, Karen M

AU - Putcha, Nirupama

AU - Adami, Alessandra

AU - Porszasz, Janos

AU - Fischer, Hans

AU - Budoff, Matthew

AU - Cannon, Dan

AU - Rossiter, Harry

AU - Sharafkhaneh, Amir

AU - Lan, Charlie

AU - Wendt, Christine

AU - Bell, Brian

AU - Foreman, Marilyn

AU - Westney, Gloria

AU - Berkowitz, Eugene

AU - Rosiello, Richard

AU - Pace, David

AU - Criner, Gerard

AU - Ciccolella, David

AU - Cordova, Francis

AU - Dass, Chandra

AU - D'Alonzo, Robert

AU - Desai, Parag

AU - Jacobs, Michael

AU - Kelsen, Steven

AU - Mamary, A. James

AU - Marchetti, Nathaniel

AU - Satti, Aditti

AU - Shenoy, Kartik

AU - Steiner, Robert M.

AU - Swift, Alex

AU - Swift, Irene

AU - Vega-Sanchez, Gloria

AU - Dransfield, Mark

AU - Wells, J. Michael

AU - Bhatt, Surya

AU - Nath, Hrudaya

AU - Ramsdell, Joe

AU - Soler, Xavier

AU - Yen, Andrew

AU - Cornellas, Alejandro

AU - Newell, John

AU - Thompson, Brad

AU - Kazerooni, Ella

AU - Martinez, Fernando

AU - Billings, Joanne

AU - Allen, Tadashi

AU - Sciurba, Frank

AU - Chandra, Divay

AU - Weissfeld, Joel

AU - Fuhrman, Carl

AU - Bon, Jessica

AU - Anzueto, Antonio

AU - Adams, Sandra

AU - Maselli-Caceres, Diego

AU - Ruiz, Mario E.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free. OBJECTIVE: To identify clinical and radiologic evidence of smoking-related disease in a cohort of current and former smokers who did not meet spirometric criteria for COPD, for whom we adopted the discarded label of Global Initiative for Obstructive Lung Disease (GOLD) 0. DESIGN, SETTING, AND PARTICIPANTS: Individuals from the Genetic Epidemiology of COPD (COPDGene) cross-sectional observational study completed spirometry, chest computed tomography (CT) scans, a 6-minute walk, and questionnaires. Participants were recruited from local communities at 21 sites across the United States. The GOLD 0 group (n = 4388) (ratio of forced expiratory volume in the first second of expiration [FEV1] to forced vital capacity >0.7 and FEV1 >80% predicted) from the COPDGene study was compared with a GOLD 1 group (n = 794), COPD groups (n = 3690), and a group of never smokers (n = 108). Recruitment began in January 2008 and ended in July 2011. MAIN OUTCOMES AND MEASURES: Physical function impairments, respiratory symptoms, CT abnormalities, use of respiratory medications, and reduced respiratory-specific quality of life. RESULTS: One or more respiratory-related impairments were found in 54.1% (2375 of 4388) of the GOLD 0 group. The GOLD 0 group had worse quality of life (mean [SD] St George's Respiratory Questionnaire total score, 17.0 [18.0] vs 3.8 [6.8] for the never smokers; P

AB - IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free. OBJECTIVE: To identify clinical and radiologic evidence of smoking-related disease in a cohort of current and former smokers who did not meet spirometric criteria for COPD, for whom we adopted the discarded label of Global Initiative for Obstructive Lung Disease (GOLD) 0. DESIGN, SETTING, AND PARTICIPANTS: Individuals from the Genetic Epidemiology of COPD (COPDGene) cross-sectional observational study completed spirometry, chest computed tomography (CT) scans, a 6-minute walk, and questionnaires. Participants were recruited from local communities at 21 sites across the United States. The GOLD 0 group (n = 4388) (ratio of forced expiratory volume in the first second of expiration [FEV1] to forced vital capacity >0.7 and FEV1 >80% predicted) from the COPDGene study was compared with a GOLD 1 group (n = 794), COPD groups (n = 3690), and a group of never smokers (n = 108). Recruitment began in January 2008 and ended in July 2011. MAIN OUTCOMES AND MEASURES: Physical function impairments, respiratory symptoms, CT abnormalities, use of respiratory medications, and reduced respiratory-specific quality of life. RESULTS: One or more respiratory-related impairments were found in 54.1% (2375 of 4388) of the GOLD 0 group. The GOLD 0 group had worse quality of life (mean [SD] St George's Respiratory Questionnaire total score, 17.0 [18.0] vs 3.8 [6.8] for the never smokers; P

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U2 - 10.1001/jamainternmed.2015.2735

DO - 10.1001/jamainternmed.2015.2735

M3 - Article

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SP - 1539

EP - 1549

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 9

ER -