Clinical and pathological analysis of spinal cord astrocytomas in children

E. Rossitch, S. M. Zeidman, P. C. Burger, J. T. Curnes, C. Harsh, M. Anscher, W. J. Oakes

Research output: Contribution to journalArticle

Abstract

Twelve children with pathologically confirmed, well-differentiated spinal cord astrocytomas were studied, and correlations among the degree of resection, pathological characteristics, and time of recurrence were examined. Eight tumors were sampled for biopsy or subtotally resected, and 4 were thought to have been totally removed. Clinical recurrence was seen in 4 of 12 patients, 2 of whom died of their disease. The time to recurrence was 1, 2, 2, and 35 years, respectively. The other 8 children remain free of symptoms, with follow-up ranging from 6 months to 35 years (mean, 8.8 years). In 3 of 8 patients who underwent biopsy or subtotal resection, the tumor recurred, and 2 patients died, whereas there was one recurrence in the patients in whom a 'total' resection had been obtained. The histologically well-differentiated nature of the lesions correlated well with the relatively prolonged clinical course seen in this series during the period of observation. The relatively long clinical courses seen in our limited series should be considered before high-risk therapy for spinal cord astrocytomas in children is implemented. The presence of four pilocytic astrocytomas in this group was of special interest, and it seems likely that these discrete neoplasms can be distinguished from the more infiltrating fibrillary astrocytic neoplasms by magnetic resonance imaging with enhancement with gadopentetate dimeglumine.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalNeurosurgery
Volume27
Issue number2
StatePublished - 1990
Externally publishedYes

Fingerprint

Astrocytoma
Spinal Cord
Recurrence
Neoplasms
Biopsy
Gadolinium DTPA
Magnetic Resonance Imaging
Observation
Therapeutics

Keywords

  • Astrocytoma
  • Spinal cord tumor

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Rossitch, E., Zeidman, S. M., Burger, P. C., Curnes, J. T., Harsh, C., Anscher, M., & Oakes, W. J. (1990). Clinical and pathological analysis of spinal cord astrocytomas in children. Neurosurgery, 27(2), 193-196.

Clinical and pathological analysis of spinal cord astrocytomas in children. / Rossitch, E.; Zeidman, S. M.; Burger, P. C.; Curnes, J. T.; Harsh, C.; Anscher, M.; Oakes, W. J.

In: Neurosurgery, Vol. 27, No. 2, 1990, p. 193-196.

Research output: Contribution to journalArticle

Rossitch, E, Zeidman, SM, Burger, PC, Curnes, JT, Harsh, C, Anscher, M & Oakes, WJ 1990, 'Clinical and pathological analysis of spinal cord astrocytomas in children', Neurosurgery, vol. 27, no. 2, pp. 193-196.
Rossitch E, Zeidman SM, Burger PC, Curnes JT, Harsh C, Anscher M et al. Clinical and pathological analysis of spinal cord astrocytomas in children. Neurosurgery. 1990;27(2):193-196.
Rossitch, E. ; Zeidman, S. M. ; Burger, P. C. ; Curnes, J. T. ; Harsh, C. ; Anscher, M. ; Oakes, W. J. / Clinical and pathological analysis of spinal cord astrocytomas in children. In: Neurosurgery. 1990 ; Vol. 27, No. 2. pp. 193-196.
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