Abstract
Acute promyelocytic leukemia (APL) is a relatively common form of acute myeloid leukemia (AML) that has an excellent prognosis. In contrast, secondary acute myeloid leukemias, including therapy-related AML and AML with myelodysplasia-related changes, have a relatively poor prognosis. We identified 9 cases of APL at our institution in which there was a history of chemotherapy, radiotherapy, chronic immunosuppression, or antecedent myelodysplastic syndrome. The clinical and pathologic findings in these cases of secondary APL were compared with the clinical and pathologic findings in cases of de novo APL. We found that secondary and de novo APL had abnormal promyelocytes with similar morphologic and immunophenotypic features, comparable cytogenetic findings, comparable rates of FMS-like tyrosine kinase mutations, and similar rates of recurrent disease and death. These data suggest that secondary APL is similar to de novo APL and, thus, should be considered distinct from other secondary acute myeloid neoplasms. Copyright
| Original language | English (US) |
|---|---|
| Pages (from-to) | 395-402 |
| Number of pages | 8 |
| Journal | American Journal of Clinical Pathology |
| Volume | 137 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2012 |
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Keywords
- Acute myeloid leukemia with myelodysplasia-related changes
- Acute promyelocytic leukemia
- APL
- Flow cytometry
- Therapy-related acute myeloid leukemia
- Therapy-related myeloid neoplasm
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Clinical and pathologic features of secondary acute promyelocytic leukemia. / Duffield, Amy S; Aoki, Joseph; Levis, Mark J; Cowan, Kathleen; Gocke, Christopher; Burns, Kathleen; Borowitz, Michael J; Vuica-Ross, Milena.
In: American Journal of Clinical Pathology, Vol. 137, No. 3, 03.2012, p. 395-402.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and pathologic features of secondary acute promyelocytic leukemia
AU - Duffield, Amy S
AU - Aoki, Joseph
AU - Levis, Mark J
AU - Cowan, Kathleen
AU - Gocke, Christopher
AU - Burns, Kathleen
AU - Borowitz, Michael J
AU - Vuica-Ross, Milena
PY - 2012/3
Y1 - 2012/3
N2 - Acute promyelocytic leukemia (APL) is a relatively common form of acute myeloid leukemia (AML) that has an excellent prognosis. In contrast, secondary acute myeloid leukemias, including therapy-related AML and AML with myelodysplasia-related changes, have a relatively poor prognosis. We identified 9 cases of APL at our institution in which there was a history of chemotherapy, radiotherapy, chronic immunosuppression, or antecedent myelodysplastic syndrome. The clinical and pathologic findings in these cases of secondary APL were compared with the clinical and pathologic findings in cases of de novo APL. We found that secondary and de novo APL had abnormal promyelocytes with similar morphologic and immunophenotypic features, comparable cytogenetic findings, comparable rates of FMS-like tyrosine kinase mutations, and similar rates of recurrent disease and death. These data suggest that secondary APL is similar to de novo APL and, thus, should be considered distinct from other secondary acute myeloid neoplasms. Copyright
AB - Acute promyelocytic leukemia (APL) is a relatively common form of acute myeloid leukemia (AML) that has an excellent prognosis. In contrast, secondary acute myeloid leukemias, including therapy-related AML and AML with myelodysplasia-related changes, have a relatively poor prognosis. We identified 9 cases of APL at our institution in which there was a history of chemotherapy, radiotherapy, chronic immunosuppression, or antecedent myelodysplastic syndrome. The clinical and pathologic findings in these cases of secondary APL were compared with the clinical and pathologic findings in cases of de novo APL. We found that secondary and de novo APL had abnormal promyelocytes with similar morphologic and immunophenotypic features, comparable cytogenetic findings, comparable rates of FMS-like tyrosine kinase mutations, and similar rates of recurrent disease and death. These data suggest that secondary APL is similar to de novo APL and, thus, should be considered distinct from other secondary acute myeloid neoplasms. Copyright
KW - Acute myeloid leukemia with myelodysplasia-related changes
KW - Acute promyelocytic leukemia
KW - APL
KW - Flow cytometry
KW - Therapy-related acute myeloid leukemia
KW - Therapy-related myeloid neoplasm
UR - http://www.scopus.com/inward/record.url?scp=84859237502&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859237502&partnerID=8YFLogxK
U2 - 10.1309/AJCPE0MV0YTWLUUE
DO - 10.1309/AJCPE0MV0YTWLUUE
M3 - Article
C2 - 22338051
AN - SCOPUS:84859237502
VL - 137
SP - 395
EP - 402
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 3
ER -