TY - JOUR
T1 - Clinical and molecular-genetic insights into the role of oxidative stress in diabetic retinopathy
T2 - Antioxidant strategies and future avenues
AU - Valencia Study Group on Diabetic Retinopathy (VSDR) Report number 4
AU - Sanz-González, Silvia M.
AU - García-Medina, José J.
AU - Zanón-Moreno, Vicente
AU - López-Gálvez, María I.
AU - Galarreta-Mira, David
AU - Duarte, Lilianne
AU - Valero-Velló, Mar
AU - Ramírez, Ana I.
AU - Arévalo, J. Fernando
AU - Pinazo-Durán, María D.
N1 - Funding Information:
Funding: This work has been done in part, with the collaboration of members assigned to the research teams of Valencia, Valladolid, and Madrid pertaining to the ophthalmology network: OFTARED (RD16-0008) of the Carlos III Health Institute (ISCIII) of the Spanish Government (Madrid, Spain). This work was funded, in part by: (1) the ISCIII-General Subdirection of Networks and Cooperative Research Centers (Madrid, Spain), (2) the European Program FEDER, and (3) by the Spanish research projects PI13/00480 and PI16/00797. Silvia M Sanz-González received a research fellowship from Thea Laboratories (Barcelona, Spain and Clermond Ferrand, France).
Funding Information:
This work has been done in part, with the collaboration of members assigned to the research teams of Valencia, Valladolid, and Madrid pertaining to the ophthalmology network: OFTARED (RD16-0008) of the Carlos III Health Institute (ISCIII) of the Spanish Government (Madrid, Spain). This work was funded, in part by: (1) the ISCIII-General Subdirection of Networks and Cooperative Research Centers (Madrid, Spain), (2) the European Program FEDER, and (3) by the Spanish research projects PI13/00480 and PI16/00797. Silvia M Sanz-Gonz?lez received a research fellowship from Thea Laboratories (Barcelona, Spain and Clermond Ferrand, France).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/11
Y1 - 2020/11
N2 - Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/ω3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (−) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/ω3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS; p = 0.006) and lower plasma total antioxidant capacity (TAC; p = 0.042) and vitamin C (0.020) was found in T2DM + DR versus T2DM-DR. The differential expression profile of solute carrier family 23 member 2 (SLC23A2) gene was seen in diabetics versus the CG (p = 0.001), and in T2DM + DR versus T2DM − DR (p < 0.05). The A/ω3 regime significantly reduced the pro-oxidants (p < 0.05) and augmented the antioxidants (p < 0.05). This follow-up study supports that a regular A/ω3 supplementation reduces the oxidative load and may serve as a dietary prophylaxis/adjunctive intervention for patients at risk of diabetic blindness.
AB - Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/ω3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (−) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/ω3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS; p = 0.006) and lower plasma total antioxidant capacity (TAC; p = 0.042) and vitamin C (0.020) was found in T2DM + DR versus T2DM-DR. The differential expression profile of solute carrier family 23 member 2 (SLC23A2) gene was seen in diabetics versus the CG (p = 0.001), and in T2DM + DR versus T2DM − DR (p < 0.05). The A/ω3 regime significantly reduced the pro-oxidants (p < 0.05) and augmented the antioxidants (p < 0.05). This follow-up study supports that a regular A/ω3 supplementation reduces the oxidative load and may serve as a dietary prophylaxis/adjunctive intervention for patients at risk of diabetic blindness.
KW - Antioxidants
KW - Candidate biomarkers
KW - Omega-3 fatty acids
KW - Oxidative stress
KW - Prevention of blindness
KW - Retinopathy
KW - Type 2 diabetes mellitus
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U2 - 10.3390/antiox9111101
DO - 10.3390/antiox9111101
M3 - Article
C2 - 33182408
AN - SCOPUS:85095841020
SN - 2076-3921
VL - 9
SP - 1
EP - 19
JO - Antioxidants
JF - Antioxidants
IS - 11
M1 - 1101
ER -