Clinical and laboratory evolution of a culture-confirmed case of human granulocytic ehrlichiosis

Deloar Hossain, Maria E. Aguero-Rosenfeld, Harold W. Horowitz, Joseph M. Wu, Tze Chen Hsieh, Neeraj Sachdeva, Stephen J. Peterson, J. Stephen Dumler, Gary P. Wormser

Research output: Contribution to journalArticle

Abstract

A 74-year-old man from suburban New York City, who was hospitalized because of chest pain and fever, was diagnosed as having human granulocytic ehrlichiosis on the eighth hospital day. Although leukocyte and platelet counts were normal on admission, they fell to abnormally low values then normalized prior to specific therapy against the human granulocytic ehrlichiosis agent. Intracytoplasmic inclusions suggestive of Ehrlichia were observed in up to six percent of granulocytes, and the human granulocytic ehrlichiosis bacterium was cultured in an HL 60 human promyelocytic cell line. The patient improved dramatically within 24 hours of doxycycline treatment, after failing to improve on various beta lactam antimicrobial agents. He was discharged from the hospital 14 days after admission. Because human granulocytic ehrlichiosis was not diagnosed until his eight hospital day, clinical and laboratory parameters prior to specific treatment were available. This case illustrates the clinical and laboratory evolution of the infection with human granulocytic ehrlichiosis agent in humans.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalConnecticut Medicine
Volume63
Issue number5
StatePublished - 1999

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Ehrlichiosis
Ehrlichia
Laboratory Infection
Doxycycline
beta-Lactams
Anti-Infective Agents
Chest Pain
Platelet Count
Leukocyte Count
Granulocytes
Fever
Therapeutics
Bacteria
Cell Line

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hossain, D., Aguero-Rosenfeld, M. E., Horowitz, H. W., Wu, J. M., Hsieh, T. C., Sachdeva, N., ... Wormser, G. P. (1999). Clinical and laboratory evolution of a culture-confirmed case of human granulocytic ehrlichiosis. Connecticut Medicine, 63(5), 265-270.

Clinical and laboratory evolution of a culture-confirmed case of human granulocytic ehrlichiosis. / Hossain, Deloar; Aguero-Rosenfeld, Maria E.; Horowitz, Harold W.; Wu, Joseph M.; Hsieh, Tze Chen; Sachdeva, Neeraj; Peterson, Stephen J.; Dumler, J. Stephen; Wormser, Gary P.

In: Connecticut Medicine, Vol. 63, No. 5, 1999, p. 265-270.

Research output: Contribution to journalArticle

Hossain, D, Aguero-Rosenfeld, ME, Horowitz, HW, Wu, JM, Hsieh, TC, Sachdeva, N, Peterson, SJ, Dumler, JS & Wormser, GP 1999, 'Clinical and laboratory evolution of a culture-confirmed case of human granulocytic ehrlichiosis', Connecticut Medicine, vol. 63, no. 5, pp. 265-270.
Hossain D, Aguero-Rosenfeld ME, Horowitz HW, Wu JM, Hsieh TC, Sachdeva N et al. Clinical and laboratory evolution of a culture-confirmed case of human granulocytic ehrlichiosis. Connecticut Medicine. 1999;63(5):265-270.
Hossain, Deloar ; Aguero-Rosenfeld, Maria E. ; Horowitz, Harold W. ; Wu, Joseph M. ; Hsieh, Tze Chen ; Sachdeva, Neeraj ; Peterson, Stephen J. ; Dumler, J. Stephen ; Wormser, Gary P. / Clinical and laboratory evolution of a culture-confirmed case of human granulocytic ehrlichiosis. In: Connecticut Medicine. 1999 ; Vol. 63, No. 5. pp. 265-270.
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