Clinical and experimental immunobiology of medulloblastomas

M. A. Gerosa, G. Semenzato, G. Amadori, Alessandro Olivi, A. Rotilio, M. Zuccarello

Research output: Contribution to journalArticle

Abstract

A wide pre- and postoperative immunological monitoring of B- and T-cell markers in children with medulloblastomas is presented. Preoperative investigations showed a noticeable failure of T-cell-dependent immunity, currently identified by 'active' E-rosette forming cells (Ea-RFC) and blastogenesis tests, with a significant increase of spontaneous cell-mediated cytotoxicity (SCMC). In postoperative long-term controls, a slight recovery of Ea-RFC and blastogenesis tests was observed. The main findings concerning cytotoxicity kinetics are discussed.

Original languageEnglish (US)
Pages (from-to)193-195
Number of pages3
JournalSurgical Neurology
Volume14
Issue number3
Publication statusPublished - 1980
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Gerosa, M. A., Semenzato, G., Amadori, G., Olivi, A., Rotilio, A., & Zuccarello, M. (1980). Clinical and experimental immunobiology of medulloblastomas. Surgical Neurology, 14(3), 193-195.