TY - JOUR
T1 - Clinical and epidemiological aspects of chronic chagas disease from southern brazil
AU - Lidani, Kárita Cláudia Freitas
AU - Sandri, Thaisa Lucas
AU - Castillo-Neyra, Ricardo
AU - Andrade, Fabiana Antunes
AU - Guimarães, Cesar Maistro
AU - Marques, Eduardo Nunes
AU - Beltrame, Marcia Holsbach
AU - Gilman, Robert Hugh
AU - de Messias-Reason, Iara
N1 - Funding Information:
We thank the Chagas Ambulatory of the Clinical Hospital of Federal University of Paraná for CD patient recruitment.This work was supported by research grants from Fundação Araucária (CP 01/2016 Programa Pesquisa para o Sistema Único de Saúde: Gestão Compartilhada em Saúde-PPSUS Edição 2015 Fundação Araucária-PR/SESA-PR/CNPq/MS-Decit), IMR; and Coordenação deAperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES), finance Code 001, for funding a scholarship to KCFL. The authors also acknowledge support by NIH (National Institutes of Health), through the National Institute of Allergy and Infectious Diseases, grant number 5R01-AI107028, RHG. We declare that the funding agencies had no involvement with study design, data analysis and interpretation, or any decision in the preparation of the manuscript.
Funding Information:
This work was supported by research grants from Fundação
Funding Information:
Araucária (CP 01/2016 Programa Pesquisa para o Sistema Único de Saúde: Gestão Compartilhada em Saúde - PPSUS Edição 2015 Fundação Araucária-PR/SESA-PR/CNPq/MS-Decit), IMR; and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES), finance Code 001, for funding a scholarship to KCFL. The authors also acknowledge support by NIH (National Institutes of Health), through the National Institute of Allergy and Infectious Diseases, grant number 5R01-AI107028, RHG. We declare that the funding agencies had no involvement with study design, data analysis and interpretation, or any decision in the preparation of the manuscript.
Publisher Copyright:
© 2020, Sociedade Brasileira de Medicina Tropical. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Introduction: Patients with Chagas disease (CD), caused by Trypanosoma cruzi, present a higher risk of developing other chronic diseases, which may contribute to CD severity. Since CD is underreported in the southern state of Paraná, Brazil, we aimed to characterize clinical and epidemiological aspects of individuals chronically infected with T. cruzi in Southern Brazil. Methods: A community hospital-based study was performed, recording clinical/demographic characteristics of 237 patients with CD from Southern Brazil. To estimate the association between different forms of CD and sociodemographic and clinical variables, multiple logistic regression models were built using the Akaike information criterion. Results: Mean age was 57.5 years and 59% were females. Most patients’ (60%) place of origin/birth was within Paraná and they were admitted to the CD outpatient clinic after presenting with cardiac/digestive symptoms (64%). The predominant form of CD was cardiac (53%), followed by indeterminate (36%), and digestive (11%). The main electrocardiographic changes were in the right bundle branch block (39%) and left anterior fascicular block (32%). The average number of comorbidities per patient was 3.9±2.3; systemic arterial hypertension was most common (64%), followed by dyslipidemia (34%) and diabetes (19%); overlapping comorbidities were counted separately. Male sex was associated with symptomatic cardiac CD (OR=2.92; 95%CI: 1.05-8.12; p=0.040). Conclusions: This study provided greater understanding of the distribution and clinical profile of CD patients in Southern Brazil, indicating a high prevalence of comorbidities among these patients who are a vulnerable group due to advanced age and substantial risk of morbidity.
AB - Introduction: Patients with Chagas disease (CD), caused by Trypanosoma cruzi, present a higher risk of developing other chronic diseases, which may contribute to CD severity. Since CD is underreported in the southern state of Paraná, Brazil, we aimed to characterize clinical and epidemiological aspects of individuals chronically infected with T. cruzi in Southern Brazil. Methods: A community hospital-based study was performed, recording clinical/demographic characteristics of 237 patients with CD from Southern Brazil. To estimate the association between different forms of CD and sociodemographic and clinical variables, multiple logistic regression models were built using the Akaike information criterion. Results: Mean age was 57.5 years and 59% were females. Most patients’ (60%) place of origin/birth was within Paraná and they were admitted to the CD outpatient clinic after presenting with cardiac/digestive symptoms (64%). The predominant form of CD was cardiac (53%), followed by indeterminate (36%), and digestive (11%). The main electrocardiographic changes were in the right bundle branch block (39%) and left anterior fascicular block (32%). The average number of comorbidities per patient was 3.9±2.3; systemic arterial hypertension was most common (64%), followed by dyslipidemia (34%) and diabetes (19%); overlapping comorbidities were counted separately. Male sex was associated with symptomatic cardiac CD (OR=2.92; 95%CI: 1.05-8.12; p=0.040). Conclusions: This study provided greater understanding of the distribution and clinical profile of CD patients in Southern Brazil, indicating a high prevalence of comorbidities among these patients who are a vulnerable group due to advanced age and substantial risk of morbidity.
KW - Cardiomyopathy
KW - Chagas disease
KW - Epidemiology
KW - Trypanosoma cruzi infection
UR - http://www.scopus.com/inward/record.url?scp=85094837369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094837369&partnerID=8YFLogxK
U2 - 10.1590/0037-8682-0559-2019
DO - 10.1590/0037-8682-0559-2019
M3 - Article
C2 - 33111908
AN - SCOPUS:85094837369
SN - 0037-8682
VL - 53
SP - 1
EP - 10
JO - Revista da Sociedade Brasileira de Medicina Tropical
JF - Revista da Sociedade Brasileira de Medicina Tropical
M1 - e20200225
ER -