Clinical and biological significance of HLA-G expression in ovarian cancer

Jim Jinn Chyuan Sheu, Ie Ming Shih

Research output: Contribution to journalReview articlepeer-review

Abstract

Ovarian cancer is the most lethal gynecologic neoplastic disease in which the molecular etiology remains largely unclear. Like other cancer types, evolution of ovarian tumor cell species is accompanied by acquisition of novel gene products and these new tumor-associated antigens elicit a host immune response that creates selection pressure upon the emerging tumor clones. One of the mechanisms that ovarian cancer cells evade immune surveillance is by upregulating human leukocyte antigen-G (HLA-G) expression. HLA-G is a non-classical MHC class I molecule and accumulated evidence has suggested its biological role in inactivating immune response. It has been well known that HLA-G expression is frequently detected in the most aggressive type of ovarian cancer, i.e., high-grade serous carcinoma, and measurement of HLA-G protein levels has shown promise for detection and prognosis prediction in ovarian cancer. This review summarizes those recent studies on HLA-G expression in ovarian cancer with special focus on its clinical and biological significance which is fundamental to elucidate the molecular mechanisms in ovarian cancer development and paves the foundation for future HLA-G-based diagnostics and therapeutics.

Original languageEnglish (US)
Pages (from-to)436-443
Number of pages8
JournalSeminars in Cancer Biology
Volume17
Issue number6
DOIs
StatePublished - Dec 2007

Keywords

  • Clinical
  • HLA-G
  • Immune
  • Lymphocytes
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research

Fingerprint

Dive into the research topics of 'Clinical and biological significance of HLA-G expression in ovarian cancer'. Together they form a unique fingerprint.

Cite this