Abstract
There have been minimal therapeutic advancements in acute myeloid leukemia (AML) over the past 4 decades and outcomes remain unsatisfactory. Alvocidib (formerly flavopiridol) is a multi-serine threonine cyclin-dependent kinase inhibitor with demonstrable in vitro and clinical activity in AML when combined in a timed sequential chemotherapy regimen, FLAM (alvocidib followed by cytarabine continuous infusion and mitoxantrone). FLAM has been evaluated in sequential phase 1 and phase 2 studies in 149 and 256 relapsed/refractory and newly diagnosed non-favorable risk AML patients, respectively, with encouraging findings in both patient populations warranting further investigation. This review highlights the mechanism of action of alvocidib, pre-clinical studies of alvocidib in AML, and the clinical trials evaluating alvocidib alone and in combination with cytotoxic agents (FLAM) in AML.
Original language | English (US) |
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Pages (from-to) | 1312-1318 |
Number of pages | 7 |
Journal | Leukemia Research |
Volume | 39 |
Issue number | 12 |
DOIs | |
State | Published - Sep 2 2015 |
Keywords
- Acute myeloid leukemia
- Alvocidib
- CDK inhibitors
- Cyclin dependent kinase
- FLAM
- Flavopiridol
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research