Clinic-pathologic features and prognostic analysis of thyroid cancer in the older adult: A SEER based study

Li Ye Shi, Jiang Liu, Lu Jiao Yu, Yi Ming Lei, Sean Leng, Hai Yan Zhang

Research output: Contribution to journalArticle

Abstract

Purpose: Age at diagnosis has been identified as a major determinant of thyroid cancer-specific survival. But the cut-off value for age was controversial. The interaction among gender, age histologic subtypes needed to be answered. Methods: We identified 59, 892 thyroid cancer (TC) patients from the Surveillance, Epidemiology, and End Results (SEER) database. We divided the patients into the following three groups according to age: 20-44 years (young), 45-64 years (middle-aged), = 65 years (elderly). Logistic regression model was used to identify factors relating to prognosis in elderly patients. Multivariable Cox regression model identified potential prognostic factors. All statistical tests were two-sided. Results: Elderly patients had significantly worse prognosis than the other two groups, P=0.001. Elderly patients had higher proportion of male gender, advanced tumor grade, follicular subtype advanced tumor stage. There was no survival difference for elderly patients to receive lobectomy total thyroidectomy, P=0.852. Cox proportional hazards regression model showed that gender, marital status, histology, tumor grade, tumor size, TNM stage, surgery radiotherapy were all independent prognostic factors in the multivariable analysis. Male patients with TC had worse prognosis than their female counterparts in differentiated tumor but not in undifferentiated tumor. There were more patients of larger tumor, advanced TNM stage histologic subtypes in male patients. Conclusions: In conclusion, there were a series of factors contributing to the poor prognosis in elderly patients including clinic-pathologic factors therapy selection. There was no survival difference for elderly patients to receive lobectomy total thyroidectomy.

Original languageEnglish (US)
Pages (from-to)2744-2750
Number of pages7
JournalJournal of Cancer
Volume9
Issue number15
DOIs
StatePublished - Jan 1 2018

Keywords

  • Clinic-pathologic Features
  • Elder
  • Prognosis
  • SEER
  • Thyroid cancer

ASJC Scopus subject areas

  • Oncology

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