Clindamycin-associated colitis in hamsters: Protection with vancomycin

J. G. Bartlett; A. B. Onderdonk; R. L. Cisneros

doi:10.1016/s0016-5085(19)31782-2

Clindamycin-associated colitis in hamsters: Protection with vancomycin

J. G. Bartlett, A. B. Onderdonk, R. L. Cisneros

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Clindamycin and lincomycin produced a lethal enterocolitis in 65 of 67 Syrian hamsters. The administration of oral or parenteral vancomycin to recipients of clindamycin or lincomycin was uniformly protective in 49 animals. These results suggest that certain bacteria play a role in the pathogenesis of enterocolitis in this model.

Original language	English (US)
Pages (from-to)	772-776
Number of pages	5
Journal	Gastroenterology
Volume	73
Issue number	4 I
DOIs	https://doi.org/10.1016/s0016-5085(19)31782-2
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/s0016-5085(19)31782-2

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title = "Clindamycin-associated colitis in hamsters: Protection with vancomycin",

abstract = "Clindamycin and lincomycin produced a lethal enterocolitis in 65 of 67 Syrian hamsters. The administration of oral or parenteral vancomycin to recipients of clindamycin or lincomycin was uniformly protective in 49 animals. These results suggest that certain bacteria play a role in the pathogenesis of enterocolitis in this model.",

author = "Bartlett, {J. G.} and Onderdonk, {A. B.} and Cisneros, {R. L.}",

year = "1977",

doi = "10.1016/s0016-5085(19)31782-2",

language = "English (US)",

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TY - JOUR

T1 - Clindamycin-associated colitis in hamsters

T2 - Protection with vancomycin

AU - Bartlett, J. G.

AU - Onderdonk, A. B.

AU - Cisneros, R. L.

PY - 1977

Y1 - 1977

N2 - Clindamycin and lincomycin produced a lethal enterocolitis in 65 of 67 Syrian hamsters. The administration of oral or parenteral vancomycin to recipients of clindamycin or lincomycin was uniformly protective in 49 animals. These results suggest that certain bacteria play a role in the pathogenesis of enterocolitis in this model.

AB - Clindamycin and lincomycin produced a lethal enterocolitis in 65 of 67 Syrian hamsters. The administration of oral or parenteral vancomycin to recipients of clindamycin or lincomycin was uniformly protective in 49 animals. These results suggest that certain bacteria play a role in the pathogenesis of enterocolitis in this model.

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U2 - 10.1016/s0016-5085(19)31782-2

DO - 10.1016/s0016-5085(19)31782-2

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EP - 776

JO - Gastroenterology

JF - Gastroenterology

IS - 4 I

ER -

Clindamycin-associated colitis in hamsters: Protection with vancomycin

Abstract

ASJC Scopus subject areas

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