Click Chemistry in the Development of Contrast Agents for Magnetic Resonance Imaging

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Abstract

ABSTRACT: Click chemistry provides fast, convenient, versatile, and reliable chemical reactions that take place between pairs of functional groups of small molecules that can be purified without chromatographic methods. Due to the fast kinetics and low or no elimination of byproducts, click chemistry is a promising approach that is rapidly gaining acceptance in drug discovery, radiochemistry, bioconjugation, and nanoscience applications. Increasing use of click chemistry in synthetic procedures or as a bioconjugation technique in diagnostic imaging is occurring because click reactions are fast, provide a quantitative yield, and produce a minimal amount of nontoxic byproducts. This review summarizes the recent application of click chemistry in magnetic resonance imaging and discusses the directions for applying novel click reactions and strategies for further improving magnetic resonance imaging performance.

Original languageEnglish (US)
JournalTopics in Magnetic Resonance Imaging
DOIs
StateAccepted/In press - Jun 29 2016

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Click Chemistry
Contrast Media
Magnetic Resonance Imaging
Radiochemistry
Diagnostic Imaging
Drug Discovery

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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