Cleft palate with autosomal recessive transmission in brittany spaniels

J. T. Richtsmeier, G. H. Sack, H. M. Grausz, L. C. Cork

Research output: Contribution to journalArticle

Abstract

In the course of maintaining a large colony of Brittany spaniels for studying a dominantly inherited motor neuron trait, cases of sporadic complete cleft palate were observed. Without intervention, the pups with cleft palate that attempt to nurse, aspirate and die. In this study, we report on the incidence of cleft palate in this dog kindred, describe the gross morphologic characteristics of the cleft, and present a morphometric analysis of the skull of two of the cleft palate pups and one unaffected pup that died at birth. Our data thus far indicate 26.9% incidence of cleft palate in the colony. Pedigree analysis indicates that this cleft palate trait is inherited as an autosomal recessive. High resolution computed tomography scans of the pup heads were used in morphometric comparison of normal and cleft palate pups. We found specific morphologic differences between the cranial base and palate of normal and cleft palate pups. Plans for future studies of the genetics and growth and development of this animal model are discussed. This canine cleft palate trait provides an ideal model for studying a malformation common in humans.

Original languageEnglish (US)
Pages (from-to)364-371
Number of pages8
JournalCleft Palate-Craniofacial Journal
Volume31
Issue number5
DOIs
StatePublished - Dec 7 1994

Keywords

  • Brittany spaniels
  • animal models
  • cleft palate
  • computed tomography
  • genetics

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology

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