@article{a19e88ef8eba45dea37fed286ea1b5d3,
title = "Cleft lip and palate: Understanding genetic and environmental influences",
abstract = "Clefts of the lip and/or palate (CLP) are common birth defects of complex aetiology. CLP can occur in isolation or as part of a broad range of chromosomal, Mendelian or teratogenic syndromes. Although there has been marked progress in identifying genetic and environmental triggers for syndromic CLP, the aetiology of the more common non-syndromic (isolated) forms remains poorly characterized. Recently, using a combination of epidemiology, careful phenotyping, genome-wide association studies and analysis of animal models, several distinct genetic and environmental risk factors have been identified and confirmed for non-syndromic CLP. These findings have advanced our understanding of developmental biology and created new opportunities for clinical translational research.",
author = "Dixon, {Michael J.} and Marazita, {Mary L.} and Beaty, {Terri H.} and Murray, {Jeffrey C.}",
note = "Funding Information: We should like to thank many colleagues who have collaborated with us over the years and in particular K. Christensen, R. Lie, A. Jugessur, A. Lidral, J. Hecht, A. Vieira, M. Shi, P. Jezewski, D. Fitzpatrick, R. Munger, P. Trainor, J. Dixon, P. Romitti, P. Nopoulos, J. Canady, B. Schutte, K. Buetow, A. Sander, G. Wehby, S. Daack-Hirsch and S. Weinberg, as well as many students. We apologize for being unable to cite all of the relevant papers. We gratefully acknowledge generous funding sources including the Medical Research Council (G0901539), Wellcome Trust (082,868), US National Institutes of Health (P50-DE016215, R01-DE08559, R01-DE016148, R01-DE014581, U01-DE018993 and U01-DE20057), the Healing Foundation and the Manchester NIHR Biomedical Research Centre.",
year = "2011",
month = mar,
doi = "10.1038/nrg2933",
language = "English (US)",
volume = "12",
pages = "167--178",
journal = "Nature Reviews Genetics",
issn = "1471-0056",
publisher = "Nature Publishing Group",
number = "3",
}