Clear cell dysplasia of the bladder: Report of a case with flow cytometric analysis

J. J. Berman, J. D. Seidman, R. Yetter, G. W. Moore

Research output: Contribution to journalArticle

Abstract

Clear cell dysplasia of the bladder is a well-described morphologic entity that has been found in association with transitional cell carcinoma of the bladder. Its biologic role in bladder tumorigenesis is unknown, and no instances of its ploidy analysis have been reported. The authors describe a case of clear cell dysplasia of the bladder found in association with a primary adenocarcinoma of the bladder. Flow cytometric analysis of bladder tissue involved by clear cell dysplasia, adenocarcinoma and cystitis cystica (all from the same bladder) demonstrated no DNA aneuploid populations. Cells from the area of clear cell dysplasia had an S + G2 + M fraction of 7%, indicating that it was a proliferative lesion. Cells from the adenocarcinoma had an S + G2 + M phase of 18%, and cells from an area of cystitis cystica had an S + G2 + M phase of 4%.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalAnalytical and Quantitative Cytology and Histology
Volume13
Issue number6
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Histology

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