Classification of schizophrenia patients with combined analysis of SNP and fMRI data based on sparse representation

Dongdong Lin, Hongbao Cao, Yu Ping Wang, Vince Daniel Calhoun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We designed a sparse representation clustering (SRC) model to select the significant single nucleotide polymorphisms (SNPs) and proposed a novel SRC with a sliding window model for functional magnetic resonance imaging (fMRI) voxels selection. Then we combined two types of data to classify schizophrenia patients from healthy controls by linear support vector machine (SVM) to achieve a better diagnosis of schizophrenia. The effectiveness of the selected variables (SNPs or voxels) was validated by the leave one out (LOO) cross-validation method. The experimental results show that our proposed SRC method can effectively select the most discriminative variables in both SNPs and fMRI data. In particular, the combination of complementary fMRI and SNP data can significantly improve the classification of schizophrenia patients, which provides new insights in the study of schizophrenia.

Original languageEnglish (US)
Title of host publicationProceedings - 2011 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2011
Pages394-397
Number of pages4
DOIs
Publication statusPublished - 2011
Externally publishedYes
Event2011 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2011 - Atlanta, GA, United States
Duration: Nov 12 2011Nov 15 2011

Other

Other2011 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2011
CountryUnited States
CityAtlanta, GA
Period11/12/1111/15/11

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Keywords

  • Combined analysis
  • Schizophrenia
  • Sparse Representation Clustering
  • Variables selection

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

Cite this

Lin, D., Cao, H., Wang, Y. P., & Calhoun, V. D. (2011). Classification of schizophrenia patients with combined analysis of SNP and fMRI data based on sparse representation. In Proceedings - 2011 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2011 (pp. 394-397). [6120472] https://doi.org/10.1109/BIBM.2011.41