Classification of schizophrenia and bipolar patients using static and time-varying resting-state FMRI brain connectivity

Barnaly Rashid; Mohammad Reza Arbabshirani; Eswar Damaraju; Robyn Millar; Mustafa S. Cetin; Godfrey D. Pearlson; Vince D. Calhoun

doi:10.1109/ISBI.2015.7163861

Classification of schizophrenia and bipolar patients using static and time-varying resting-state FMRI brain connectivity

Barnaly Rashid, Mohammad Reza Arbabshirani, Eswar Damaraju, Robyn Millar, Mustafa S. Cetin, Godfrey D. Pearlson, Vince D. Calhoun

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

Recently, there is a growing interest in designing objective prognostic/diagnostic tools based on neuroimaging and other data that display high accuracy and robustness. Small training subjects and very large amount of high dimensional data make it a challenging task to design robust and accurate classifiers for heterogeneous disorders such as schizophrenia. Majority of previous works have focused on classification of schizophrenia from healthy controls while automatic differential diagnosis of schizophrenia from bipolar disorder has been rarely investigated. In this work, we propose a framework for automatic classification of schizophrenia, bipolar and healthy control subjects based on static and dynamic functional network connectivity (FNC) features. Our results show that disrupted functional integration in schizophrenia and bipolar patients as captured by FNC analysis reveal powerful information for automatic discriminative analysis.

Original language	English (US)
Title of host publication	2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015
Publisher	IEEE Computer Society
Pages	251-254
Number of pages	4
ISBN (Electronic)	9781479923748
DOIs	https://doi.org/10.1109/ISBI.2015.7163861
State	Published - Jul 21 2015
Event	12th IEEE International Symposium on Biomedical Imaging, ISBI 2015 - Brooklyn, United States Duration: Apr 16 2015 → Apr 19 2015

Publication series

Name	Proceedings - International Symposium on Biomedical Imaging
Volume	2015-July
ISSN (Print)	1945-7928
ISSN (Electronic)	1945-8452

Other

Other	12th IEEE International Symposium on Biomedical Imaging, ISBI 2015
Country/Territory	United States
City	Brooklyn
Period	4/16/15 → 4/19/15

Keywords

bipolar
classification
dynamic functional network connectivity
fMRI
schizophrenia

ASJC Scopus subject areas

Biomedical Engineering
Radiology Nuclear Medicine and imaging

Access to Document

10.1109/ISBI.2015.7163861

Cite this

Rashid, B., Arbabshirani, M. R., Damaraju, E., Millar, R., Cetin, M. S., Pearlson, G. D., & Calhoun, V. D. (2015). Classification of schizophrenia and bipolar patients using static and time-varying resting-state FMRI brain connectivity. In 2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015 (pp. 251-254). Article 7163861 (Proceedings - International Symposium on Biomedical Imaging; Vol. 2015-July). IEEE Computer Society. https://doi.org/10.1109/ISBI.2015.7163861

Classification of schizophrenia and bipolar patients using static and time-varying resting-state FMRI brain connectivity. / Rashid, Barnaly; Arbabshirani, Mohammad Reza; Damaraju, Eswar et al.
2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015. IEEE Computer Society, 2015. p. 251-254 7163861 (Proceedings - International Symposium on Biomedical Imaging; Vol. 2015-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Rashid, B, Arbabshirani, MR, Damaraju, E, Millar, R, Cetin, MS, Pearlson, GD & Calhoun, VD 2015, Classification of schizophrenia and bipolar patients using static and time-varying resting-state FMRI brain connectivity. in 2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015., 7163861, Proceedings - International Symposium on Biomedical Imaging, vol. 2015-July, IEEE Computer Society, pp. 251-254, 12th IEEE International Symposium on Biomedical Imaging, ISBI 2015, Brooklyn, United States, 4/16/15. https://doi.org/10.1109/ISBI.2015.7163861

Rashid B, Arbabshirani MR, Damaraju E, Millar R, Cetin MS, Pearlson GD et al. Classification of schizophrenia and bipolar patients using static and time-varying resting-state FMRI brain connectivity. In 2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015. IEEE Computer Society. 2015. p. 251-254. 7163861. (Proceedings - International Symposium on Biomedical Imaging). doi: 10.1109/ISBI.2015.7163861

Rashid, Barnaly ; Arbabshirani, Mohammad Reza ; Damaraju, Eswar et al. / Classification of schizophrenia and bipolar patients using static and time-varying resting-state FMRI brain connectivity. 2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015. IEEE Computer Society, 2015. pp. 251-254 (Proceedings - International Symposium on Biomedical Imaging).

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Classification of schizophrenia and bipolar patients using static and time-varying resting-state FMRI brain connectivity

Abstract

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Keywords

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