TY - JOUR
T1 - Classification of Proliferative Pulmonary Lesions of the Mouse
T2 - Recommendations of the Mouse Models of Human Cancers Consortium
AU - Nikitin, Alexander Yu
AU - Alcaraz, Ana
AU - Anver, Miriam R.
AU - Bronson, Roderick T.
AU - Cardiff, Robert D.
AU - Dixon, Darlene
AU - Fraire, Armando E.
AU - Gabrielson, Edward W.
AU - Gunning, William T.
AU - Haines, Diana C.
AU - Kaufman, Matthew H.
AU - Linnoila, R. Ilona
AU - Maronpot, Robert R.
AU - Rabson, Alan S.
AU - Reddick, Robert L.
AU - Rehm, Sabine
AU - Rozengurt, Nora
AU - Schuller, Hildegard M.
AU - Shmidt, Elena N.
AU - Travis, William D.
AU - Ward, Jerrold M.
AU - Jacks, Tyler
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challenge for pathologists and investigators. Frequently, phenotypes of new models either have no precedents or are arbitrarily attributed according to incongruent human and mouse classifications. Thus, comparative characterization and validation of novel models can be difficult. To address these issues, a series of discussions was initiated by a panel of human, veterinary, and experimental pathologists during the Mouse Models of Human Cancers Consortium (NIH/National Cancer Institute) workshop on mouse models of lung cancer held in Boston on June 20-22, 2001. The panel performed a comparative evaluation of 78 cases of mouse and human lung proliferative lesions, and recommended development of a new practical classification scheme that would (a) allow easier comparison between human and mouse lung neoplasms, (b) accommodate newly emerging mouse neoplasms, and (c) address the interpretation of benign and preinvasive lesions of the mouse lung. Subsequent discussions with additional experts in pulmonary pathology resulted in the current proposal of a new classification. It is anticipated that this classification, as well as the complementary digital atlas of virtual histological slides, will help investigators and pathologists in their characterization of new mouse models, as well as stimulate further research aimed at a better understanding of proliferative lesions of the lung.
AB - Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challenge for pathologists and investigators. Frequently, phenotypes of new models either have no precedents or are arbitrarily attributed according to incongruent human and mouse classifications. Thus, comparative characterization and validation of novel models can be difficult. To address these issues, a series of discussions was initiated by a panel of human, veterinary, and experimental pathologists during the Mouse Models of Human Cancers Consortium (NIH/National Cancer Institute) workshop on mouse models of lung cancer held in Boston on June 20-22, 2001. The panel performed a comparative evaluation of 78 cases of mouse and human lung proliferative lesions, and recommended development of a new practical classification scheme that would (a) allow easier comparison between human and mouse lung neoplasms, (b) accommodate newly emerging mouse neoplasms, and (c) address the interpretation of benign and preinvasive lesions of the mouse lung. Subsequent discussions with additional experts in pulmonary pathology resulted in the current proposal of a new classification. It is anticipated that this classification, as well as the complementary digital atlas of virtual histological slides, will help investigators and pathologists in their characterization of new mouse models, as well as stimulate further research aimed at a better understanding of proliferative lesions of the lung.
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U2 - 10.1158/0008-5472.CAN-03-3376
DO - 10.1158/0008-5472.CAN-03-3376
M3 - Review article
C2 - 15059877
AN - SCOPUS:11144355464
SN - 0008-5472
VL - 64
SP - 2307
EP - 2316
JO - Cancer Research
JF - Cancer Research
IS - 7
ER -