TY - JOUR
T1 - Classification of hypersensitivity reactions
AU - Dispenza, Melanie C.
N1 - Funding Information:
the Ernest S. Bazley Grant to Northwestern Memorial Hospital and Northwestern University
Publisher Copyright:
Copyright © 2019, OceanSide Publications, Inc., U.S.A.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - As the primary defense against pathogens, the immune system uses numerous strategies to ensure optimal protection for the host. When immune responses go awry, however, they can cause great damage. “Hypersensitivity” is a broad term used to describe an excessive and/or pathogenic immune response to either foreign or self antigens. Gell and Coombs were the first to categorize hypersensitivity reactions into 4 types according to pathophysiology, but more recent insights into the mechanisms of these disorders have since modified the original classification system. This review describes the immune mechanisms involved in each of the modern Gell-Coombs categories.
AB - As the primary defense against pathogens, the immune system uses numerous strategies to ensure optimal protection for the host. When immune responses go awry, however, they can cause great damage. “Hypersensitivity” is a broad term used to describe an excessive and/or pathogenic immune response to either foreign or self antigens. Gell and Coombs were the first to categorize hypersensitivity reactions into 4 types according to pathophysiology, but more recent insights into the mechanisms of these disorders have since modified the original classification system. This review describes the immune mechanisms involved in each of the modern Gell-Coombs categories.
UR - http://www.scopus.com/inward/record.url?scp=85074742156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074742156&partnerID=8YFLogxK
U2 - 10.2500/aap.2019.40.4274
DO - 10.2500/aap.2019.40.4274
M3 - Article
C2 - 31690397
AN - SCOPUS:85074742156
SN - 1088-5412
VL - 40
SP - 470
EP - 473
JO - Allergy and Asthma Proceedings
JF - Allergy and Asthma Proceedings
IS - 6
ER -