Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging

Ilfet Songun, Cornelis J H Van De Velde, Jan W. Arends, Paul Blok, A. Joris K Grond, G. Johan A Offerhaus, Jo Hermans, Joannes H J M Van Krieken

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Due to the high variability of the epidemiology, genetics, morphology, and biologic behavior of gastric carcinoma, many classification systems are in use, e.g., the World Health Organization (WHO) classification; tumor differentiation; the criteria of Ming, Mulligan, and Lauren; and the recently introduced Goseki classification. In the authors' opinion, the TNM staging is the most valuable classification system, with a prognostic value for survival. METHODS. To assess the reproducibility and usefulness of these systems in clinical practice, material from 285 gastric carcinoma patients entered in the Dutch Gastric Cancer Trial was analyzed by a panel of 5 experienced gastrointestinal pathologists. The presence of eosinophilic and lymphocytic infiltrates was analyzed in addition to the TNM staging. RESULTS. Of the analyzed classification systems, only TNM stage, tumor differentiation, eosinophilic infiltrate, and the Goseki system contained information associated with the survival of patients with gastric carcinoma. The reproducibility was perfect for tumor differentiation (Kappa 1.00), nearly perfect for the WHO and Goseki classifications (Kappa 0.86 and 0.87, respectively), reasonably good for Lauren and lymphocytic infiltrate (Kappa 0.70), and reasonably good for eosinophilic infiltrate (Kappa 0.42). CONCLUSIONS. Of all these systems, the Goseki classification was the only system with prognostic value that is additional to TNM staging.

Original languageEnglish (US)
Pages (from-to)2114-2118
Number of pages5
JournalCancer
Volume85
Issue number10
DOIs
StatePublished - May 15 1999
Externally publishedYes

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Neoplasm Staging
Stomach
Carcinoma
Neoplasms
Survival
Molecular Epidemiology
Information Systems
Stomach Neoplasms

Keywords

  • Classification systems
  • Gastric carcinoma
  • Prognostic value
  • Reproducibility

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Songun, I., Van De Velde, C. J. H., Arends, J. W., Blok, P., Grond, A. J. K., Offerhaus, G. J. A., ... Van Krieken, J. H. J. M. (1999). Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging. Cancer, 85(10), 2114-2118. https://doi.org/10.1002/(SICI)1097-0142(19990515)85:10<2114::AID-CNCR3>3.0.CO;2-U

Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging. / Songun, Ilfet; Van De Velde, Cornelis J H; Arends, Jan W.; Blok, Paul; Grond, A. Joris K; Offerhaus, G. Johan A; Hermans, Jo; Van Krieken, Joannes H J M.

In: Cancer, Vol. 85, No. 10, 15.05.1999, p. 2114-2118.

Research output: Contribution to journalArticle

Songun, I, Van De Velde, CJH, Arends, JW, Blok, P, Grond, AJK, Offerhaus, GJA, Hermans, J & Van Krieken, JHJM 1999, 'Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging', Cancer, vol. 85, no. 10, pp. 2114-2118. https://doi.org/10.1002/(SICI)1097-0142(19990515)85:10<2114::AID-CNCR3>3.0.CO;2-U
Songun, Ilfet ; Van De Velde, Cornelis J H ; Arends, Jan W. ; Blok, Paul ; Grond, A. Joris K ; Offerhaus, G. Johan A ; Hermans, Jo ; Van Krieken, Joannes H J M. / Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging. In: Cancer. 1999 ; Vol. 85, No. 10. pp. 2114-2118.
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AU - Arends, Jan W.

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AU - Grond, A. Joris K

AU - Offerhaus, G. Johan A

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AB - BACKGROUND. Due to the high variability of the epidemiology, genetics, morphology, and biologic behavior of gastric carcinoma, many classification systems are in use, e.g., the World Health Organization (WHO) classification; tumor differentiation; the criteria of Ming, Mulligan, and Lauren; and the recently introduced Goseki classification. In the authors' opinion, the TNM staging is the most valuable classification system, with a prognostic value for survival. METHODS. To assess the reproducibility and usefulness of these systems in clinical practice, material from 285 gastric carcinoma patients entered in the Dutch Gastric Cancer Trial was analyzed by a panel of 5 experienced gastrointestinal pathologists. The presence of eosinophilic and lymphocytic infiltrates was analyzed in addition to the TNM staging. RESULTS. Of the analyzed classification systems, only TNM stage, tumor differentiation, eosinophilic infiltrate, and the Goseki system contained information associated with the survival of patients with gastric carcinoma. The reproducibility was perfect for tumor differentiation (Kappa 1.00), nearly perfect for the WHO and Goseki classifications (Kappa 0.86 and 0.87, respectively), reasonably good for Lauren and lymphocytic infiltrate (Kappa 0.70), and reasonably good for eosinophilic infiltrate (Kappa 0.42). CONCLUSIONS. Of all these systems, the Goseki classification was the only system with prognostic value that is additional to TNM staging.

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