Classification of Blood Culture Isolates into Contaminants and Pathogens on the Basis of Clinical and Laboratory Data

Belal Hossain, Martin W. Weber, Davidson H. Hamer, Patricia L. Hibberd, A. S M Nawshad Uddin Ahmed, Mahfuza Marzan, Maksuda Islam, Nicholas E. Connor, Mohammad Shahidul Islam, Anita K. Zaidi, Abdullah Baqui, Zulfiqar A. Bhutta, Shahida M. Qureshi, Iftekhar Rafiqullah, Lesley McGee, Samir K. Saha

Research output: Contribution to journalArticle

Abstract

The multisite community-based study, Aetiology of Neonatal Infection in South Asia (ANISA), uses blood culture as the gold standard for identifying the etiology of neonatal infection. Considering the importance of this age-old diagnostic tool and the risk of contamination, ANISA has employed rigorous measures to prevent contamination at all stages of blood collection, processing and culture. Because contamination may still occur, an independent expert group evaluates the routinely collected clinical and laboratory data to determine whether a blood culture isolate is a contaminant or a true pathogen. This article describes the methodology used by ANISA to determine whether a blood culture isolate is likely to be a true pathogen or a contaminant in neonatal sepsis.

Original languageEnglish (US)
Pages (from-to)S52-S54
JournalPediatric Infectious Disease Journal
Volume35
Issue number5
DOIs
StatePublished - May 1 2016

Keywords

  • ANISA
  • blood culture
  • contamination
  • infection
  • neonate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

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    Hossain, B., Weber, M. W., Hamer, D. H., Hibberd, P. L., Ahmed, A. S. M. N. U., Marzan, M., Islam, M., Connor, N. E., Islam, M. S., Zaidi, A. K., Baqui, A., Bhutta, Z. A., Qureshi, S. M., Rafiqullah, I., McGee, L., & Saha, S. K. (2016). Classification of Blood Culture Isolates into Contaminants and Pathogens on the Basis of Clinical and Laboratory Data. Pediatric Infectious Disease Journal, 35(5), S52-S54. https://doi.org/10.1097/INF.0000000000001107