Classification, morphology, molecular pathogenesis, and outcome of premalignant lesions of the pancreas

Meredith E. Pittman, Rema Rao, Ralph H. Hruban

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Invasive pancreatic ductal adenocarcinoma has a greater than 90% mortality rate at 5 years. Understanding noninvasive, curable precursor lesions gives us the best hope for reducing mortality from pancreatic ductal adenocarcinoma. The 3 pancreatic precursor lesions that have been well studied include intraductal papillary mucinous neoplasm, mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia. Objective: To give an update on the latest clinical, molecular, and pathologic advances in intraductal papillary mucinous neoplasm, mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia for the general surgical pathologist. Data Sources: The current literature was analyzed and the authors' experiences with institutional and consult material were incorporated. Conclusions: Our understanding of the molecular alterations that lead from pancreatic precursor lesion to invasive carcinoma continues to evolve. These advances aid clinicians in their treatment decisions and researchers in their search for actionable, druggable targets.

Original languageEnglish (US)
Pages (from-to)1606-1614
Number of pages9
JournalArchives of Pathology and Laboratory Medicine
Volume141
Issue number12
DOIs
StatePublished - Dec 2017

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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