TY - JOUR
T1 - Classification and pathogenesis of proliferative sickle retinopathy
AU - Goldberg, Morton F.
N1 - Funding Information:
From the Departments of Ophthalmology and the Divison of Medical Genetics, The Johns Hopkins Hospital, Baltimore, Maryland. Supported in part by the Bailey Fund of the Wilmer Institute and by USPHS Special Fellowship 2F11 NB01675-02VSN.
PY - 1971/3
Y1 - 1971/3
N2 - The ocular fundi of 24 selected patients with sickle cell-hemoglobin C disease were studied by indirect ophthalmoscopy and fluorescein angiography. Based on these studies, a new, quantitative classification of proliferative sickle retinopathy (PSR) was devised, which reflects both increasing severity of the retinopathy as well as its natural progression. The first sign of PSR is peripheral arteriolar occlusions (Stage I); 91% of eyes were affected. Peripheral arteriolar-venular anastomoses (Stage II) were observed in 85% of eyes. Neovascular and fibrous proliferations (Stage III), which develop from the A-V anastomoses, occurred in 81% of eyes. Seafan lesions are part of this stage. Vitreous hemorrhages (Stage IV) from the neovascular proliferations occurred in approximately 30% of eyes, and retinal detachment (Stage V) was observed in 8% of eyes. Pathogenetic parallels appear to exist between PSR and other vasoproliferative disorders, such as diabetes mellitus, hypotensive vascular diseases, and retrolental fibroplasia.
AB - The ocular fundi of 24 selected patients with sickle cell-hemoglobin C disease were studied by indirect ophthalmoscopy and fluorescein angiography. Based on these studies, a new, quantitative classification of proliferative sickle retinopathy (PSR) was devised, which reflects both increasing severity of the retinopathy as well as its natural progression. The first sign of PSR is peripheral arteriolar occlusions (Stage I); 91% of eyes were affected. Peripheral arteriolar-venular anastomoses (Stage II) were observed in 85% of eyes. Neovascular and fibrous proliferations (Stage III), which develop from the A-V anastomoses, occurred in 81% of eyes. Seafan lesions are part of this stage. Vitreous hemorrhages (Stage IV) from the neovascular proliferations occurred in approximately 30% of eyes, and retinal detachment (Stage V) was observed in 8% of eyes. Pathogenetic parallels appear to exist between PSR and other vasoproliferative disorders, such as diabetes mellitus, hypotensive vascular diseases, and retrolental fibroplasia.
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U2 - 10.1016/0002-9394(71)90429-6
DO - 10.1016/0002-9394(71)90429-6
M3 - Article
C2 - 5546311
AN - SCOPUS:0015026175
SN - 0002-9394
VL - 71
SP - 649
EP - 665
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 3
ER -