Classics in chemical neuroscience: Diazepam (valium)

Nicholas E. Calcaterra, James Barrow

Research output: Contribution to journalReview article

Abstract

Diazepam (Valium) is among the most successful drugs from the onset of the psychopharmacological revolution that began during the 1950s. Efficacious in treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set the standard for pharmacotherapy in terms of potency, onset of action, and safety. In this Review, the legacy of diazepam to chemical neuroscience will be considered along with its synthesis, pharmacology, drug metabolism, adverse events and dependence, clinical use, and regulatory issues.

Original languageEnglish (US)
Pages (from-to)253-260
Number of pages8
JournalACS Chemical Neuroscience
Volume5
Issue number4
DOIs
StatePublished - Apr 16 2014

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Diazepam
Neurosciences
Drug therapy
Anxiety Disorders
Drug-Related Side Effects and Adverse Reactions
Metabolism
Pharmaceutical Preparations
Epilepsy
Pharmacology
Safety
Drug Therapy

Keywords

  • anxiety
  • benzodiazepine
  • Diazepam
  • GABA
  • hypnotic
  • sedative
  • Valium

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Physiology
  • Cognitive Neuroscience
  • Medicine(all)

Cite this

Classics in chemical neuroscience : Diazepam (valium). / Calcaterra, Nicholas E.; Barrow, James.

In: ACS Chemical Neuroscience, Vol. 5, No. 4, 16.04.2014, p. 253-260.

Research output: Contribution to journalReview article

Calcaterra, Nicholas E. ; Barrow, James. / Classics in chemical neuroscience : Diazepam (valium). In: ACS Chemical Neuroscience. 2014 ; Vol. 5, No. 4. pp. 253-260.
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