Classics in chemical neuroscience: Diazepam (valium)

Nicholas E. Calcaterra; James C. Barrow

doi:10.1021/cn5000056

Classics in chemical neuroscience: Diazepam (valium)

Nicholas E. Calcaterra, James C. Barrow

Research output: Contribution to journal › Review article › peer-review

98 Scopus citations

Abstract

Diazepam (Valium) is among the most successful drugs from the onset of the psychopharmacological revolution that began during the 1950s. Efficacious in treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set the standard for pharmacotherapy in terms of potency, onset of action, and safety. In this Review, the legacy of diazepam to chemical neuroscience will be considered along with its synthesis, pharmacology, drug metabolism, adverse events and dependence, clinical use, and regulatory issues.

Original language	English (US)
Pages (from-to)	253-260
Number of pages	8
Journal	ACS Chemical Neuroscience
Volume	5
Issue number	4
DOIs	https://doi.org/10.1021/cn5000056
State	Published - Apr 16 2014
Externally published	Yes

Keywords

Diazepam
GABA
Valium
anxiety
benzodiazepine
hypnotic
sedative

ASJC Scopus subject areas

Biochemistry
Physiology
Cognitive Neuroscience
Cell Biology

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10.1021/cn5000056

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Classics in chemical neuroscience: Diazepam (valium)

Abstract

Keywords

ASJC Scopus subject areas

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