Class II transactivator suppresses transcription of thyroid-specific genes

Atsumi Mori-Aoki, Michelle Pietrarelli, Minoru Nakazato, Patrizio Caturegli, Leonard D. Kohn, Koichi Suzuki

Research output: Contribution to journalArticle

Abstract

Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume278
Issue number1
DOIs
StatePublished - Nov 11 2000

Keywords

  • Antigen presentation
  • Autoimmunity
  • Gene regulation
  • MHC
  • Thyroid
  • Transcription factors

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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