Class II transactivator suppresses transcription of thyroid-specific genes

Atsumi Mori-Aoki, Michelle Pietrarelli, Minoru Nakazato, Patrizio P Caturegli, Leonard D. Kohn, Koichi Suzuki

Research output: Contribution to journalArticle

Abstract

Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume278
Issue number1
DOIs
StatePublished - Nov 11 2000

Fingerprint

Transcription
Thyroid Gland
Genes
Interferon-gamma
Rats
MHC Class II Genes
Thyroid Diseases
Autoimmune Diseases
Cells
MHC class II transactivator protein
Gene Expression
Cell Line

Keywords

  • Antigen presentation
  • Autoimmunity
  • Gene regulation
  • MHC
  • Thyroid
  • Transcription factors

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Class II transactivator suppresses transcription of thyroid-specific genes. / Mori-Aoki, Atsumi; Pietrarelli, Michelle; Nakazato, Minoru; Caturegli, Patrizio P; Kohn, Leonard D.; Suzuki, Koichi.

In: Biochemical and Biophysical Research Communications, Vol. 278, No. 1, 11.11.2000, p. 58-62.

Research output: Contribution to journalArticle

Mori-Aoki, Atsumi ; Pietrarelli, Michelle ; Nakazato, Minoru ; Caturegli, Patrizio P ; Kohn, Leonard D. ; Suzuki, Koichi. / Class II transactivator suppresses transcription of thyroid-specific genes. In: Biochemical and Biophysical Research Communications. 2000 ; Vol. 278, No. 1. pp. 58-62.
@article{2b77713db1ec4dd1b1cde078cb8b9c5a,
title = "Class II transactivator suppresses transcription of thyroid-specific genes",
abstract = "Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.",
keywords = "Antigen presentation, Autoimmunity, Gene regulation, MHC, Thyroid, Transcription factors",
author = "Atsumi Mori-Aoki and Michelle Pietrarelli and Minoru Nakazato and Caturegli, {Patrizio P} and Kohn, {Leonard D.} and Koichi Suzuki",
year = "2000",
month = "11",
day = "11",
doi = "10.1006/bbrc.2000.3769",
language = "English (US)",
volume = "278",
pages = "58--62",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Class II transactivator suppresses transcription of thyroid-specific genes

AU - Mori-Aoki, Atsumi

AU - Pietrarelli, Michelle

AU - Nakazato, Minoru

AU - Caturegli, Patrizio P

AU - Kohn, Leonard D.

AU - Suzuki, Koichi

PY - 2000/11/11

Y1 - 2000/11/11

N2 - Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.

AB - Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.

KW - Antigen presentation

KW - Autoimmunity

KW - Gene regulation

KW - MHC

KW - Thyroid

KW - Transcription factors

UR - http://www.scopus.com/inward/record.url?scp=0034638597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034638597&partnerID=8YFLogxK

U2 - 10.1006/bbrc.2000.3769

DO - 10.1006/bbrc.2000.3769

M3 - Article

C2 - 11071855

AN - SCOPUS:0034638597

VL - 278

SP - 58

EP - 62

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -